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The influence of adhesive and invasive properties of Staphylococcus aureus defective in fibronectin-binding proteins on secretion of interleukin-6 by human endothelial cells
Örebro universitet, Institutionen för klinisk medicin.ORCID-id: 0000-0001-5939-2932
Örebro universitet, Institutionen för klinisk medicin.ORCID-id: 0000-0003-2625-4597
2006 (engelsk)Inngår i: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 114, nr 2, 112-116 s.Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Fibronectin-binding proteins (FnBP) are surface adhesins of Staphylococcus aureus documented to be virulence attributes in, for example, endovascular infections. By using mutants of S. aureus defective in the FnBPA and B genes we have investigated whether these adhesins affect cytokine expression in human umbilical vein endothelial cells (HUVEC). S. aureus expressing FnBPA and B adhered to and were internalized into HUVEC to a greater extent compared to mutants defective in expression of FnBP. Production and release of IL-6 was higher from endothelial cells infected with the parent FnBP-expressing strain compared to the FnBP-defective mutants. These results indicate that adhesion to and invasion of S. aureus into endothelial cells are important regulators of cytokine expression.

sted, utgiver, år, opplag, sider
2006. Vol. 114, nr 2, 112-116 s.
HSV kategori
Forskningsprogram
Medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-12046DOI: 10.1111/j.1600-0463.2006.apm_319.xPubMedID: 16519747OAI: oai:DiVA.org:oru-12046DiVA: diva2:355118
Tilgjengelig fra: 2010-10-05 Laget: 2010-10-05 Sist oppdatert: 2017-12-12bibliografisk kontrollert

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