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Aberrant Amino Acid Transport in Patients with Schizophrenia, Bipolar-I Disorders and Autism
Örebro universitet, Institutionen för hälsovetenskap och medicin. (Experimental Neuropsychiatry)ORCID-id: 0000-0001-8102-1804
2011 (engelsk)Inngår i: Psychiatry and the neurosciences: international perspectives, Bologna, Italy: Medimond, 2011, s. 155-161Konferansepaper, Publicerat paper (Annet vitenskapelig)
Abstract [en]

Tyrosine and tryptophan are precursors to dopamine and serotonin and are involved in partial regulation of dopamine and serotonin synthesis. Changes in tyrosine and or tryptophan availability may influence dopamine-serotonin function that may cause widespread changes both in neurotransmission and psychopathology in patients with schizophrenia, bipolar-I and related CNS disorders. Competitive transport with other amino acids or aberrant transport of these precursors, across the cell membranes/blood brain barrier (BBB), can cause a limited availability of tyrosine and/or tryptophan to the brain. Transport of neutral amino acids including tyrosine, tryptophan and alanine, mainly occurs through L and A system and its isoforms. Evidence from different investigations of an aberrant amino acid transport in fibroblast cell obtain from patients with schizophrenia, bipolar-I disorders and autism, as well as the functionality and the relationship between tyrosine, tryptophan and alanine transport are touched on in this article

sted, utgiver, år, opplag, sider
Bologna, Italy: Medimond, 2011. s. 155-161
Serie
Neurology, Psychiatry and the Neurosciences ; 50
Emneord [en]
Amino acid, transport, fibroblaster, schizophrenia, autism
HSV kategori
Forskningsprogram
Psykiatri; Biomedicin; Medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-25374ISI: 000309762400020ISBN: 978-88-7587-618-0 (tryckt)OAI: oai:DiVA.org:oru-25374DiVA, id: diva2:547305
Konferanse
the 4th International Congress on Psychiatry and the Neurosciences
Prosjekter
Aminosyratransport i fibroblaster från patienter med schizofreni och bipolär sjukdom
Forskningsfinansiär
Swedish Research Council, K2007-62X-08318Tilgjengelig fra: 2012-08-30 Laget: 2012-08-27 Sist oppdatert: 2018-05-04bibliografisk kontrollert

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