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Biotransformation of fluorotelomer compund to perfluorocarboxylates in humans
Örebro universitet, Institutionen för naturvetenskap och teknik.ORCID-id: 0000-0003-3722-4633
Örebro universitet, Institutionen för naturvetenskap och teknik.
Örebro universitet, Institutionen för naturvetenskap och teknik.
Örebro universitet, Institutionen för naturvetenskap och teknik.ORCID-id: 0000-0001-6217-8857
Vise andre og tillknytning
(engelsk)Manuskript (preprint) (Annet vitenskapelig)
HSV kategori
Forskningsprogram
Kemi
Identifikatorer
URN: urn:nbn:se:oru:diva-25984OAI: oai:DiVA.org:oru-25984DiVA, id: diva2:556122
Merknad

Under review in Environmental International 2012-08-14.

Tilgjengelig fra: 2012-09-24 Laget: 2012-09-24 Sist oppdatert: 2017-10-17bibliografisk kontrollert
Inngår i avhandling
1. Occupational exposure to fluorinated ski wax
Åpne denne publikasjonen i ny fane eller vindu >>Occupational exposure to fluorinated ski wax
2012 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Per- and polyfluorinated substances (PFAS) are used in the production of ski wax to reduce the friction between the snow and the ski. In this occupational study of ski wax technicians’ exposure to PFAS and particulate aerosol we have collected whole blood (wb) (n =94), air (n =84) and aerosol (n =159) samples at World Cup events from 2007-2011.

We have analysed the blood, air and aerosol with respect to 13 perfluorocarboxylic acids (PFCAs), 4 perfluorosulfonic acids (PFSAs), 3 fluorotelomer alcohols (FTOHs), 3 fluorotelomer acids (FTCAs) and 3 unsaturated fluorotelomer acids (FTUCAs). Further, we assessed the exposure to 3 particulate aerosol fractions (inhalable, respirable and total aerosol) in air.

In comparison to a general population, several of the PFCA blood levels are elevated in the technicians’, primarily  erfluorooctanoate (PFOA) and perfluorononate (PFNA) with concentrations up to 628 and 163 ng/mL wb, respectively. Further,  we detected FTUCAs and FTCAs in the blood, suggesting biotransformation of FTOHs to PFCAs. The metabolites 5:3 and 7:3 FTCA were detected in all blood samples at levels up to 6.1 and 3.9 ng/mL wb. Levels of perfluorohexadecanoic acid PFHxDA) and perfluorooctadecanoic acid (PFOcDA) were detected in the technician’s blood at mean concentration up to 4.22 ng/mL wb and 4.25 ng/mL wb.

The FTOH levels in air of the wax cabin during work ranged up to 997 000 ng/m3 (average=114 000 ng/m3 ) and PFOA up to 4 890 ng/m3 (average= 526 ng/m3 . FTOHs were not detected in aerosols but PFOA showed average levels of 12 000 ng/m3 (range=1 230- 46 900 ng/m3 ).

The occupational exposure limit (OEL) of 2 mg/m3 was exceeded in 37% of the personal measurements with aerosol  concentrations up to 15 mg/m3 . Keywords : Perfluorinated, polyfluorinated, FIS, occupational exposure, ski wax,  iotransformation, metabolism, fluorotelomer alcohol, fluorotelomer acid, aerosol, dust, UPLC/MS-MS, GC/MS-MS

sted, utgiver, år, opplag, sider
Örebro: Örebro universitet, 2012. s. 73
Serie
Örebro Studies in Chemistry, ISSN 1651-4270 ; 11
Emneord
Perfluorinated, polyfluorinated, FIS, occupational exposure, ski wax, biotransformation, metabolism, fluorotelomer alcohol, fluorotelomer acid, aerosol, dust, UPLC/MS-MS, GC/MS-MS
HSV kategori
Forskningsprogram
Kemi
Identifikatorer
urn:nbn:se:oru:diva-24289 (URN)978-91-7668-887-8 (ISBN)
Disputas
2012-09-28, Hörsal P2, Prismahuset, Örebro universitet, Falultetsgatan 1, Örebro, 10:00 (engelsk)
Opponent
Tilgjengelig fra: 2012-08-07 Laget: 2012-08-07 Sist oppdatert: 2017-10-17bibliografisk kontrollert

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Nilsson, HelenaKärrman, AnnaRotander, Annavan Bavel, BertLindström, GunillaWestberg, Håkan

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