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Prognostic impact of human papilloma virus (HPV) genotyping and HPV-16 subtyping in vaginal carcinoma
Örebro universitet, Institutionen för hälsovetenskap och medicin. Region Örebro län.
Örebro universitet, Institutionen för läkarutbildning. Örebro University Hospital, Region Örebro County, Örebro, Sweden.ORCID-id: 0000-0003-2317-5738
Örebro University Hospital, Region Örebro County, Örebro, Sweden.
Örebro University Hospital, Region Örebro County, Örebro, Sweden.ORCID-id: 0000-0002-5063-631X
Vise andre og tillknytning
2013 (engelsk)Inngår i: Gynecologic Oncology, ISSN 0090-8258, E-ISSN 1095-6859, Vol. 129, nr 2, s. 406-411Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective

The objectives of this study are to investigate the human papilloma virus (HPV) distribution in vaginal cancer and to evaluate HPV-genotype as well as HPV16-variant impact on prognosis.

Methods

Sixty-nine patients diagnosed with primary vaginal carcinoma (1975-2002) were included in the study. Detection of twelve high-risk HPV (hr HPV) and two low-risk HPV (lr HPV) was performed with realtime-PCR. Samples positive for HPV-16 were analyzed for variants in the E6-gene with PCR and pyrosequencing.

Results

53.6% (37/69) of the tumors were found to be HPV-positive, mostly for HPV-16 (N=26). Other HPV-types were HPV-18 (N=2), HPV-31 (N=2), HPV-33 (N=2), HPV-45 (N=1), HPV-52 (N=2), HPV-56 (N=1) and HPV-58 (N=1). Only European subtypes of HPV-16 were represented and the two most common HPV-16-variants were E-p (N=13) and E-G350 (N=11). Patients with HPV-positive tumors (N=37) had a significantly (log-rank test=3341; p = 0.0008) superior 5-year overall survival rate as well as cancer-specific survival rate and progression-free survival rate (p = 0.0002; p = 0.0004), compared with patients with HPV-negative tumors (N=32). Interestingly, patients with HPV-16-positive tumors had a superior overall survival compared with patients with tumors containing other HPV-genotypes. In a Cox proportional multivariate analysis age, tumor size, and HPV-status were independent and significant prognostic factors with regard to overall survival rate.

Conclusions

HPV-status is of prognostic importance in vaginal carcinoma and varies with viral genotype. In this era of HPV-vaccination, genotypes other than those included in the vaccination program could still lead to vaginal carcinoma with unfavorable prognosis.

sted, utgiver, år, opplag, sider
2013. Vol. 129, nr 2, s. 406-411
Emneord [en]
Vaginal carcinoma, Human papilloma virus, HPV-16-variants, Prognosis
HSV kategori
Forskningsprogram
Biomedicin
Identifikatorer
URN: urn:nbn:se:oru:diva-29270DOI: 10.1016/j.ygyno.2013.02.004ISI: 000318058600024PubMedID: 23402906Scopus ID: 2-s2.0-84876292443OAI: oai:DiVA.org:oru-29270DiVA, id: diva2:624343
Tilgjengelig fra: 2013-05-31 Laget: 2013-05-31 Sist oppdatert: 2018-05-18bibliografisk kontrollert
Inngår i avhandling
1. Characterization of HPV-induced vaginal and vulvar carcinoma
Åpne denne publikasjonen i ny fane eller vindu >>Characterization of HPV-induced vaginal and vulvar carcinoma
2014 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
sted, utgiver, år, opplag, sider
Örebro: Örebro university, 2014. s. 83
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 112
Emneord
vaginal carcinoma, vulvar carcinoma, HPV, integration, methylation, genotyping
HSV kategori
Forskningsprogram
Medicin
Identifikatorer
urn:nbn:se:oru:diva-38173 (URN)978-91-7529-052-2 (ISBN)
Disputas
2014-12-19, Universitetssjukhuset, Wilandersalen, Södra Grev Rosengatan, Örebro, 09:00 (svensk)
Opponent
Veileder
Tilgjengelig fra: 2014-10-27 Laget: 2014-10-27 Sist oppdatert: 2017-10-17bibliografisk kontrollert

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Lillsunde-Larsson, GabriellaHelenius, GiselaSorbe, BengtKarlsson, Mats G.

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