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Persistent organic pollutants and liver dysfunction biomarkers in a population-based human sample of men and women
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
Örebro universitet, Institutionen för naturvetenskap och teknik.ORCID-id: 0000-0001-5752-4196
Örebro universitet, Institutionen för naturvetenskap och teknik.ORCID-id: 0000-0001-6217-8857
Vise andre og tillknytning
2014 (engelsk)Inngår i: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 134, s. 251-256Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background and objective: Persistent organic pollutants (POPs) are stable organic compounds generated through different industrial activities. Liver is involved in the metabolism of POPs, and hence exposure to POPs may interfere with liver function. Although a few studies have shown adverse effects of POPs on liver function, large-scale studies involving humans are lacking. We performed this large population-based cross-sectional study to assess the associations between different POPs and liver dysfunction biomarkers.

Methods: A total of 992 individuals (all aged 70 years, 50% males) were recruited as part of Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. The total toxic equivalency (TEQ) value was calculated for seven mono-ortho and two non-ortho substituted polychlorinated biphenyls (PCBs) and octachloro-p-dibenzodioxin (OCDD) to assess their toxicological effects. The association of TEQ values, summary measures of 16 PCBs (sum of PCBs) and three organochlorine pesticides (sum of OC pesticides) with liver dysfunction biomarkers (bilirubin; alkaline phosphatase, ALP; alanine amino-transferase, ALT; and gamma-glutamyltransferase, GGT) was analyzed utilizing linear regression analysis.

Results: The mono-ortho PCB TEQ values were found to be significantly positively associated with bilirubin (beta=0.71, P=0.008), while sum of OC pesticide concentrations was negatively associated with ALP (beta= -0.02, P=0.002) after adjusting for various potential confounders. When analyzed individually, a number of different POPs were associated with ALP, ALT and bilirubin. No such association with GGT was observed.

Conclusion: Various POPs including PCBs, OCDD and pesticides were associated with the liver dysfunction biomarkers bilirubin, ALT and ALP, suggesting adverse effects on liver function from these environmental pollutants. (C) 2014 Elsevier Inc. All rights reserved.

sted, utgiver, år, opplag, sider
2014. Vol. 134, s. 251-256
Emneord [en]
Cross-sectional study, Human population, Liver dysfunction markers, Persistent organic pollutants
HSV kategori
Forskningsprogram
Miljövetenskap
Identifikatorer
URN: urn:nbn:se:oru:diva-42372DOI: 10.1016/j.envres.2014.07.023ISI: 000346817100034PubMedID: 25173059Scopus ID: 2-s2.0-84907375296OAI: oai:DiVA.org:oru-42372DiVA, id: diva2:785651
Forskningsfinansiär
Swedish Heart Lung FoundationSwedish Research Council, 2012-2407
Merknad

Funding Agency:

Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS) 2007-2047

Tilgjengelig fra: 2015-02-03 Laget: 2015-02-03 Sist oppdatert: 2018-01-11bibliografisk kontrollert

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