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Low colonization rates of Clostridium difficile among patients and healthcare workers at Örebro University Hospital in Sweden
Örebro universitet, Institutionen för medicinska vetenskaper. Faculty of Medicine and Health, Department of Infectious Diseases, Örebro University, Örebro, Sweden.ORCID-id: 0000-0003-1999-3383
Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden; , Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Örebro universitet, Institutionen för läkarutbildning. Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden; , Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.
2015 (engelsk)Inngår i: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 123, nr 3, s. 240-244Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The aim of this study was to investigate the rate of asymptomatic colonization rate of Clostridium difficile among both healthcare workers (HCWs) and patients in a hospital ward in Sweden. In a prospective observational study, asymptomatic HCWs (n=22) (22/60; 37%) attending patients in an infectious disease ward in Sweden participated and were screened once for C. difficile. At the same time, 58 consecutive patients (58/227; 26%) admitted to the same ward were screened for C. difficile, first at admission and thereafter two times weekly. Fecal samples were obtained by rectal swabs and cultured anaerobically using both cycloserine-cefoxitin-fructose agar and enrichment (Cooked Meat broth). All samples were also tested by loop-mediated isothermal amplification and isolates were tested for the presence of toxin A or B by enzyme immunoassay. None of the analyzed fecal samples from HCWs contained C. difficile. Among the patients during a 2-month observational period, three of the 58 patients (5.2%) were culture positive regarding C. difficile on admission and one additional patient became asymptomatically colonized with C. difficile during the hospital stay. Thus, the colonization rates were 0% (0/22) (95% confidence interval (CI): 0-15.4%) among HCWs and 5.2% (3/58) (95% CI: 1.1-14.4%) among patients at admission. As the HCWs were screened only once, we have not studied transient colonization. In conclusion, with observed low colonization rates, we find no support that HCWs would be an important source for C. difficile transmission.

sted, utgiver, år, opplag, sider
2015. Vol. 123, nr 3, s. 240-244
Emneord [en]
Clostridium difficile, healthcare worker, colonization, Clostridium difficile infection, Prevalence
HSV kategori
Forskningsprogram
Immunologi
Identifikatorer
URN: urn:nbn:se:oru:diva-43934DOI: 10.1111/apm.12353ISI: 000350298700009PubMedID: 25627981Scopus ID: 2-s2.0-84923481212OAI: oai:DiVA.org:oru-43934DiVA, id: diva2:799196
Tilgjengelig fra: 2015-03-30 Laget: 2015-03-30 Sist oppdatert: 2018-09-04bibliografisk kontrollert

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