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Significance of an exon 2 G4C14-to-A4T14 polymorphism in the p73 gene on survival in rectal cancer patients with or without preoperative radiotherapy
University of Linköping.
University of Linköping.
Karolinska University Hospital, Stockholm, Sweden.
University of Linköping.
2009 (engelsk)Inngår i: Radiotherapy and Oncology, ISSN 0167-8140, E-ISSN 1879-0887, Vol. 92, nr 2, s. 215-20Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND AND PURPOSE: An exon 2 G4C14-->A4T14 polymorphism in the p73 gene was shown to be related to survival in several types of cancers, including colorectal cancer. The purpose was to investigate if this polymorphism was related to survival in rectal cancer patients with or without preoperative radiotherapy.

MATERIALS AND METHODS: DNA extracted from tissue of 138 rectal cancer patients that received preoperative radiotherapy or had surgery alone was typed for the polymorphism by PCR using confronting two-pair primers.

RESULTS: Among patients, 69% had GC/GC genotype, 27% had GC/AT and 4% had AT/AT. In the radiotherapy group, patients carrying the AT (GC/AT+AT/AT) allele had stronger expression of p53 (p=0.001) and survivin protein (p=0.03) than those carrying the GC/GC genotype. Further, among patients receiving preoperative radiotherapy the GC/GC genotype tended to be related to better survival (p=0.20). Patients with GC/GC genotype, along with negative p53 and weak survivin expression showed better survival than the other patients (p=0.03), even after adjusting for TNM stage and tumor differentiation (p=0.01, RR, 7.63, 95% CI, 1.50-38.74). In the non-radiotherapy group, the polymorphism was not related to survival (p=0.74).

CONCLUSIONS: Results suggest that the p73 G4C14-->A4T14 polymorphism could be one factor influencing outcome of preoperative radiotherapy in rectal cancer patients.

sted, utgiver, år, opplag, sider
2009. Vol. 92, nr 2, s. 215-20
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-44361DOI: 10.1016/j.radonc.2009.06.007ISI: 000269088400009PubMedID: 19581013Scopus ID: 2-s2.0-67650992087OAI: oai:DiVA.org:oru-44361DiVA, id: diva2:806455
Forskningsfinansiär
Swedish Cancer Society
Merknad

Funding Agency: Health Research Council in the South-East of Sweden

Tilgjengelig fra: 2015-04-20 Laget: 2015-04-20 Sist oppdatert: 2022-11-25bibliografisk kontrollert
Inngår i avhandling
1. Molecular studies of radiotherapy and chemotherapy in colorectal cancer
Åpne denne publikasjonen i ny fane eller vindu >>Molecular studies of radiotherapy and chemotherapy in colorectal cancer
2015 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
sted, utgiver, år, opplag, sider
Örebro: Örebro university, 2015. s. 73
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 122
Emneord
Colorectal cancer, Radiotherapy, Chemotherapy, p53, p73, PINCH, miRNAs
HSV kategori
Forskningsprogram
Biomedicin
Identifikatorer
urn:nbn:se:oru:diva-43635 (URN)978-91-7529-070-6 (ISBN)
Disputas
2015-05-29, Prismahuset, Hörsal 2, Örebro universitet, Fakultetsgatan 1, Örebro, 13:00 (svensk)
Opponent
Veileder
Forskningsfinansiär
Swedish Cancer SocietySwedish Research Council
Merknad

Funding Agency:

Health Research Council in the South-East of Sweden

Tilgjengelig fra: 2015-03-16 Laget: 2015-03-16 Sist oppdatert: 2024-03-05bibliografisk kontrollert

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