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Laparoscopic gastric bypass: comparison of outcomes from a randomised controlled trial and a concurrent observational study
Örebro universitet, Institutionen för medicinska vetenskaper. Department of Surgery.ORCID-id: 0000-0003-4958-1611
Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
(engelsk)Manuskript (preprint) (Annet vitenskapelig)
HSV kategori
Forskningsprogram
Kirurgi
Identifikatorer
URN: urn:nbn:se:oru:diva-52069OAI: oai:DiVA.org:oru-52069DiVA, id: diva2:967470
Tilgjengelig fra: 2016-09-09 Laget: 2016-09-08 Sist oppdatert: 2017-10-17bibliografisk kontrollert
Inngår i avhandling
1. Preventing complications in bariatric surgery
Åpne denne publikasjonen i ny fane eller vindu >>Preventing complications in bariatric surgery
2016 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Obesity is a major public health problem. Bariatric surgery is currently the only available treatment that offers sufficient weight-loss and metabolic benefits over time. Although bariatric surgery is considered safe now, serious complications still occur. The aim of this thesis was to identify factors associated with an increased risk for postoperative complication after laparoscopic gastric bypass surgery.

Study I included patients operated with laparoscopic gastric bypass surgery in Sweden from May 2007 until September 2012. The risk for serious complication was low (3.4%). Suffering an intraoperative adverse event or conversion of the operation to open surgery were the strongest risk factors for postoperative complication. The annual operative volume and experience of the procedure at the institution were also important risk factors. Patient-specific risk factors appeared to be less important although age was associated with an increased risk. In Study II, a raised glycated haemoglobin A1c (HbA1c) was evaluated as a risk factor for serious postoperative complications in non-diabetics. A higher incidence of serious postoperative complications was seen with elevated HbA1c values, even at levels classified as ‘‘pre-diabetic’’.

Study III was a multicentre, randomised clinical trial (RCT). 2507 patients planned for laparoscopic gastric bypass surgery were randomised to either mesenteric defects closure or non-closure. Closure of the mesenteric defects reduced the rate of reoperation for small bowel obstruction from 10.2% to 5.5% at 3 years after surgery. A small increase in the rate of serious postoperative complication within the first 30 days was seen with mesenteric defects closure. This relatively small increase in risk was however outweighed by the marked reduction of later reoperations for small bowel obstruction.

Study IV was a comparison between study III and an observational study on the same population under the same period of time. Although the observational study reached the same conlusion as the RCT, the efficacy of mesenteric defects closure was less pronounced. Observational studies may thus be an alternative to RCTs under situations when RCTs are not feasible. The efficacy may however be underestimated.

sted, utgiver, år, opplag, sider
Örebro: Örebro university, 2016. s. 103
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 147
Emneord
postoperative complications, bariatric surgery, morbid obesity, risk factor, randomised clinical trial, haemoglobin A1c, prevention
HSV kategori
Forskningsprogram
Kirurgi
Identifikatorer
urn:nbn:se:oru:diva-50649 (URN)978-91-7529-149-9 (ISBN)
Disputas
2016-10-07, Campus USÖ, hörsal C1, Södra Grev Rosengatan 32, Örebro, 09:00 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2016-06-09 Laget: 2016-06-09 Sist oppdatert: 2017-10-18bibliografisk kontrollert

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