oru.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Medication for Attention-Deficit/Hyperactivity Disorder and Risk for Depression: A Nationwide Longitudinal Cohort Study
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Psychological and Brain Sciences, Indiana University, Bloomington, USA.
Department of Psychological and Brain Sciences, Indiana University, Bloomington, USA.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Visa övriga samt affilieringar
2016 (Engelska)Ingår i: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 80, nr 12, s. 916-922Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Attention-deficit/hyperactivity disorder (ADHD) is associated with high rates of psychiatric comorbidity, including depression. However, it is unclear whether ADHD medication increases or decreases the risk for depression.

Methods: We studied all individuals with a diagnosis of ADHD born between 1960 and 1998 in Sweden (N = 38,752). We obtained data for prescription of ADHD medication, diagnosis of depression and other psychiatric disorders, and sociodemographic factors from population-based registers. The association between ADHD medication and depression was estimated with Cox proportional hazards regression.

Results: After adjustment for sociodemographic and clinical confounders, ADHD medication was associated with a reduced long-term risk (i.e., 3 years later) for depression (hazard ratio = 0.58; 95% confidence interval, 0.51-0.67). The risk was lower for longer duration of ADHD medication. Also, ADHD medication was associated with reduced rates of concurrent depression; within-individual analysis suggested that occurrence of depression was 20% less common during periods when patients received ADHD medication compared with periods when they did not (hazard ratio = 0.80; 95% confidence interval, 0.70-0.92).

Conclusions Our study suggests that ADHD medication does not increase the risk of later depression; rather, medication was associated with a reduced risk for subsequent and concurrent depression.

Ort, förlag, år, upplaga, sidor
New York: Elsevier, 2016. Vol. 80, nr 12, s. 916-922
Nyckelord [en]
ADHD medication, Cohort study, Depression, Long-term effect, Short-term effect, Stimulants
Nationell ämneskategori
Psykiatri Neurologi
Identifikatorer
URN: urn:nbn:se:oru:diva-54106DOI: 10.1016/j.biopsych.2016.02.018ISI: 000392754000007PubMedID: 27086545Scopus ID: 2-s2.0-84963520617OAI: oai:DiVA.org:oru-54106DiVA, id: diva2:1058328
Forskningsfinansiär
Vetenskapsrådet, 2013-2280Forte, Forskningsrådet för hälsa, arbetsliv och välfärd, 2014-2780
Anmärkning

Funding Agencies:

Swedish Initiative for Research on Microdata in the Social And Medical Sciences 340-2013-5867

National Institute of Mental Health 1R01MH102221

Indiana Clinical and Translational Sciences Institute TL1 TR001107

Tillgänglig från: 2016-12-20 Skapad: 2016-12-20 Senast uppdaterad: 2018-07-23Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Personposter BETA

Larsson, Henrik

Sök vidare i DiVA

Av författaren/redaktören
Larsson, Henrik
Av organisationen
Institutionen för medicinska vetenskaper
I samma tidskrift
Biological Psychiatry
PsykiatriNeurologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 345 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf