oru.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Systematic review of environmental risk factors for Obsessive-Compulsive Disorder: A proposed roadmap from association to causation
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID-id: 0000-0002-6851-3297
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
2016 (Engelska)Ingår i: Neuroscience and Biobehavioral Reviews, ISSN 0149-7634, E-ISSN 1873-7528, Vol. 65, s. 36-62Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Objective: To synthesize the current knowledge on possible environmental risk factors for Obsessive-Compulsive Disorder (OCD).

Method: We conducted a systematic review following PRISMA guidelines. The Embase, PubMed and Scopus databases were searched up until October 6, 2015, employing relevant keywords and MeSH terms.

Results: 128 studies met inclusion criteria. Potential environmental risk factors for OCD have been identified in the broad areas of perinatal complications, reproductive cycle, and stressful life events. There is limited evidence regarding other potential risk factors, such as parental age, season of birth, socioeconomic status, parental rearing practices, infections, traumatic brain injury, substance use or vitamin deficiency. In general, studies were of limited methodological quality.

Conclusions: At present, no environmental risk factors have convincingly been associated with OCD. We propose a roadmap for future studies, consisting of longitudinal, population-based research, employing quasi-experimental family and twin designs to identify risk factors that are not only associated with the disorder but also contribute to its causation either directly or moderating the effect of genes.

Ort, förlag, år, upplaga, sidor
Oxford, United Kingdom: Elsevier, 2016. Vol. 65, s. 36-62
Nyckelord [en]
Obsessive-Compulsive disorder, genes, environment, risk factors, perinatal complications, reproductive cycle events, stressful life events, infection, PANDAS, socioeconomic status, substance abuse, traumatic brain injury, vitamin deficiency, famine, immigration, adoption, urbanization
Nationell ämneskategori
Medicin och hälsovetenskap Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:oru:diva-54637DOI: 10.1016/j.neubiorev.2016.03.011ISI: 000376787400003PubMedID: 27013116Scopus ID: 2-s2.0-84961909193OAI: oai:DiVA.org:oru-54637DiVA, id: diva2:1064486
Anmärkning

Funding Agency:

Karolinska Institutet 

Tillgänglig från: 2017-01-12 Skapad: 2017-01-12 Senast uppdaterad: 2018-01-13Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Personposter BETA

Larsson, Henrik

Sök vidare i DiVA

Av författaren/redaktören
Larsson, Henrik
I samma tidskrift
Neuroscience and Biobehavioral Reviews
Medicin och hälsovetenskapNeurovetenskaper

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 344 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf