oru.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Suicide in Tourette's and Chronic Tic Disorders
Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden.
Visa övriga samt affilieringar
2017 (Engelska)Ingår i: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 82, nr 2, s. 111-118Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Persons with neuropsychiatric disorders are at increased risk of suicide, but there is little data concerning Tourette's and chronic tic disorders (TD/CTD). We aimed to quantify the risk of suicidal behavior in a large nationwide cohort of patients with TD/CTD, establish the contribution of psychiatric comorbidity to this risk, and identify predictors of suicide.

Methods: Using a validated algorithm, we identified 7736 TD/CTD cases in the Swedish National Patient Register during a 44-year period (1969-2013). Using a matched case-cohort design, patients were compared with general population control subjects (1:10 ratio). Risk of suicidal behavior was estimated using conditional logistic regressions. Predictors of suicidal behavior in the TD/CTD cohort were studied using Cox regression models.

Results: In unadjusted models, TD/CTD patients, compared with control subjects, had an increased risk of both dying by suicide (odds ratio: 4.39; 95% confidence interval [CI]: 2.89-6.67) and attempting suicide (odds ratio: 3.86; 95% CI: 3.50-4.26). After adjusting for psychiatric comorbidities, the risk was reduced but remained substantial. Persistence of tics beyond young adulthood and a previous suicide attempt were the strongest predictors of death by suicide in TD/CTD patients (hazard ratio: 11.39; 95% CI: 3.71-35.02, and hazard ratio: 5.65; 95% CI: 2.21-14.42, respectively).

Conclusions: TD/CTD are associated with substantial risk of suicide. Suicidal behavior should be monitored in these patients, particularly in those with persistent tics, history of suicide attempts, and psychiatric comorbidities. Preventive and intervention strategies aimed to reduce the suicidal risk in this group are warranted.

Ort, förlag, år, upplaga, sidor
Elsevier, 2017. Vol. 82, nr 2, s. 111-118
Nyckelord [en]
Chronic tic disorder, Premature mortality, Psychiatric epidemiology, Suicide, Suicide attempt, Tourette’s disorder
Nationell ämneskategori
Psykiatri Neurologi
Forskningsämne
Psykiatri; Neurologi
Identifikatorer
URN: urn:nbn:se:oru:diva-54658DOI: 10.1016/j.biopsych.2016.08.023ISI: 000403670500007PubMedID: 27773353OAI: oai:DiVA.org:oru-54658DiVA, id: diva2:1064516
Forskningsfinansiär
Forte, Forskningsrådet för hälsa, arbetsliv och välfärd, 2015-00569 2015-00075Vetenskapsrådet, K2013-61P-22168
Anmärkning

Funding Agencies:

David and Astrid Hagelen Foundation  

KID (Karolinska Institutet Ph.D. stipend)

American Foundation for Suicide Prevention  

Indiana Clinical and Translational Sciences Institute  

Shire Pharmaceuticals 

Tillgänglig från: 2017-01-12 Skapad: 2017-01-12 Senast uppdaterad: 2017-10-22Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Larsson, Henrik

Sök vidare i DiVA

Av författaren/redaktören
Larsson, Henrik
Av organisationen
Institutionen för medicinska vetenskaper
I samma tidskrift
Biological Psychiatry
PsykiatriNeurologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 328 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf