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Comparison of Human Adipose-Derived Stem Cells and Bone Marrow-Derived Stem Cells in a Myocardial Infarction Model
Dept Biomed Pulm & Cardiovasc Pharmacol, Aarhus Univ, Aarhus, Denmark; Dept Hlth Sci & Technol, Lab Stem Cell Res, Aalborg Univ, Aalborg, Denmark.
Region Örebro län. Department of Cardiology, Örebro University Hospital, Örebro, Sweden.
Head & Heart Ctr, Dept Cardiol, Århus Univ Hosp, Århus, Denmark; Head & Heart Ctr, Dept Cardiol, Aalborg Hosp, Aalborg, Denmark.
Ctr Heart, Cardiac Stem Cell Lab, Copenhagen Univ Hosp (Rigshosp), Copenhagen, Denmark.
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2014 (Engelska)Ingår i: Cell Transplantation, ISSN 0963-6897, E-ISSN 1555-3892, Vol. 23, nr 2, s. 195-206Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Treatment of myocardial infarction (MI) with bone marrow-derived mesenchymal stem cells and recently also adipose-derived stem cells has shown promising results. In contrast to clinical trials and their use of autologous bone marrow-derived cells from the ischemic patient, the animal MI models are often using young donors and young, often immune-compromised, recipient animals. Our objective was to compare bone marrow-derived mesenchymal stem cells with adipose-derived stem cells from an elderly ischemic patient in the treatment of MI using a fully grown non-immune-compromised rat model. Mesenchymal stem cells were isolated from adipose tissue and bone marrow and compared with respect to surface markers and proliferative capability. To compare the regenerative potential of the two stem cell populations, male Sprague Dawley rats were randomized to receive intramyocardial injections of adipose-derived stem cells, bone marrow-derived mesenchymal stem cells, or phosphate-buffered saline 1 week following induction of MI. After 4 weeks, left ventricular ejection fraction (LVEF) was improved in the adipose-derived stem cell group, and scar wall thickness was greater compared with the saline group. Adipose-derived as well as bone marrow-derived mesenchymal stem cells prevented left ventricular end diastolic dilation. Neither of the cell groups displayed increased angiogenesis in the myocardium compared with the saline group. Adipose-derived stem cells from a human ischemic patient preserved cardiac function following MI, whereas this could not be demonstrated for bone marrow-derived mesenchymal stem cells, with only adipose-derived stem cells leading to an improvement in LVEF. Neither of the stem cell types induced myocardial angiogenesis, raising the question whether donor age and health have an effect on the efficacy of stem cells used in the treatment of MI.

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Cognizant Communication Corporation, 2014. Vol. 23, nr 2, s. 195-206
Nyckelord [en]
Myocardial infarction, Cell therapy, Left ventricular function, Remodeling, Angiogenesis
Nationell ämneskategori
Cell- och molekylärbiologi
Identifikatorer
URN: urn:nbn:se:oru:diva-56704DOI: 10.3727/096368912X659871ISI: 000331680300005PubMedID: 23211469Scopus ID: 2-s2.0-84893324697OAI: oai:DiVA.org:oru-56704DiVA, id: diva2:1083731
Tillgänglig från: 2017-03-22 Skapad: 2017-03-22 Senast uppdaterad: 2018-06-24Bibliografiskt granskad

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Fröbert, OleFink, Trine
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