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Epilepsy, anti-epileptic drugs, and serious transport accidents: A nationwide cohort study
University Hospital, Linköping, Sweden.
Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet, Stockholm, Sweden.
Visa övriga samt affilieringar
(Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
Nationell ämneskategori
Allmänmedicin
Identifikatorer
URN: urn:nbn:se:oru:diva-59097OAI: oai:DiVA.org:oru-59097DiVA, id: diva2:1131635
Tillgänglig från: 2017-08-15 Skapad: 2017-08-15 Senast uppdaterad: 2018-01-13Bibliografiskt granskad
Ingår i avhandling
1. Comorbidity and complications in neurological diseases
Öppna denna publikation i ny flik eller fönster >>Comorbidity and complications in neurological diseases
2017 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Background: Neurological diseases are complex and many share etiology as well as comorbidities. Epilepsy, a brain disorder characterized by an enduring predisposition to generate epileptic seizures and autism spectrum disorder (ASD), are considered to be associated, but the connection is still not fully uncovered. Cerebral palsy (CP), a lifelong, nonspecific, non-progressive disorder of posture and movement control, and Ehlers-Danlos Syndrome (EDS), a connective tissue disorder, both have many consequences for health and wellbeing throughout life.

Aims: The aim of this thesis was to explore the impact of comorbidity and complications in neurological diseases and EDS. The objective was to gain information on the nature of the connection between epilepsy and ASD, if EDS, ASD and CP have consequences for pregnancy outcome, and the risk of traffic accidents in individuals with epilepsy.

Materials and methods: The studies are all historical observational population- based cohort studies with prospectively collected data from national registers. The risk of ASD was analysed in 85,201 individuals with epilepsy and compared with 425,760 controls as well as for their firstdegree relatives. In a cohort of 1,248,178 singleton births, 314 births to women with EDS, 2,072 births to women with ASD, and 770 births to women with CP, pregnancy outcome was explored. The risk of traffic accidents was estimated in 29,220 individuals with epilepsy and 267,637 matched controls.

Results: There is an increased risk of; ASD in individuals with epilepsy and their relatives, moderately preterm birth and pre-eclampsia in maternal ASD, of preterm birth in maternal CP and transport accidents in individuals with epilepsy. There is no increased risk of adverse pregnancy outcome in women with EDS.

Conclusions: This thesis found proofs of a bidirectional association between epilepsy and ASD, that ASD and CP have consequences for pregnancy outcome and epilepsy is a risk factor for traffic accidents.

Ort, förlag, år, upplaga, sidor
Örebro: Örebro University, 2017. s. 81
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 163
Nyckelord
antiepileptic drugs, autism, cerebral palsy, child, Ehlers-Danlos Syndrome, epilepsy, obstetric, pregnancy, traffic accidents
Nationell ämneskategori
Allmänmedicin
Identifikatorer
urn:nbn:se:oru:diva-58056 (URN)978-91-7529-199-4 (ISBN)
Disputation
2017-09-08, Örebro universitet, Campus USÖ, Hörsal C3, Södra Grev Rosengatan 32, Örebro, 13:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2017-06-15 Skapad: 2017-06-15 Senast uppdaterad: 2018-01-13Bibliografiskt granskad

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