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Relationships between serum-induced AhR bioactivity or mitochondrial inhibition and circulating polychlorinated biphenyls (PCBs)
Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.
Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.
Department of Internal Medicine, College of Medicine, Eulji University, Seoul, South Korea.
Örebro universitet, Institutionen för naturvetenskap och teknik. (MTM Research Centre)ORCID-id: 0000-0001-5752-4196
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2017 (Engelska)Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, artikel-id 9383Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Metabolic syndrome and mitochondrial dysfunction have been linked to elevated serum levels of persistent organic pollutants (POPs). However, it is not clear which specific POPs contribute to aryl hydrocarbon receptor (AhR)-dependent bioactivity or inhibit mitochondrial function in human subjects. Here, we measured the cumulative bioactivity of AhR ligand mixture (AhR bioactivity) and the effects on mitochondrial function (ATP concentration) in recombinant Hepa1c1c7 cells incubated with raw serum samples obtained from 911 elderly subjects in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. Plasma concentrations of 30 POPs and plastic chemicals have previously been determined in the same PIVUS subjects. Linear regression analysis demonstrated that total toxic equivalence (TEQ) values and polychlorinated biphenyls (PCBs) were significantly correlated with AhR bioactivity (positively) and ATP concentration (negatively). Serum AhR bioactivities were positively associated with some PCBs, regardless of their dioxin-like properties, but only dioxin-like PCBs stimulated AhR bioactivity. By contrast, PCBs mediated a reduction in ATP content independently of their dioxin-like properties. This study suggests that AhR bioactivity and ATP concentrations in serum-treated cells may be valuable surrogate biomarkers of POP exposure and could be useful for the estimation of the effects of POPs on human health.

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Nature Publishing Group, 2017. Vol. 7, artikel-id 9383
Nationell ämneskategori
Farmakologi och toxikologi
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URN: urn:nbn:se:oru:diva-60719DOI: 10.1038/s41598-017-09774-1ISI: 000408441600107PubMedID: 28839207Scopus ID: 2-s2.0-85028042887OAI: oai:DiVA.org:oru-60719DiVA, id: diva2:1140185
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Funding Agency:

Korean Health Technology R&D Project, Ministry of Health Welfare  HI14C2700

Tillgänglig från: 2017-09-11 Skapad: 2017-09-11 Senast uppdaterad: 2018-01-13Bibliografiskt granskad

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Salihovic, Samiravan Bavel, Bert

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