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Absolute lung size and the sex difference in breathlessness in the general population
Department of Respiratory Medicine and Allergology, Institution for Clinical Sciences, Lund University, Lund, Sweden .
Örebro universitet, Institutionen för medicinska vetenskaper. Department of Respiratory Medicine, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden .
Uppsala University, Uppsala, Sweden .
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2018 (Engelska)Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, nr 1, artikel-id e0190876Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: Breathlessness is associated with major adverse health outcomes and is twice as common in women as men in the general population. We evaluated whether this is related to their lower absolute lung volumes.

METHODS: Cross-sectional analysis of the population-based Swedish CardioPulmonarybioImage Study (SCAPIS) Pilot, including static spirometry and diffusing capacity (n = 1,013; 49% women). Breathlessness was measured using the modified Medical Research Council (mMRC) scale and analyzed using ordinal logistic regression adjusting for age, pack-years of smoking, body mass index, chronic airway limitation, asthma, chronic bronchitis, depression and anxiety in all models.

RESULTS: Breathlessness was twice as common in women as in men; adjusted odds ratio (OR) 2.20 (95% confidence interval, 1.32-3.66). Lower absolute lung volumes were associated with increased breathlessness prevalence in both men and women. The sex difference in breathlessness was unchanged when adjusting for lung function in %predicted, but disappeared when controlling for absolute values of total lung capacity (OR 1.12; 0.59-2.15), inspiratory capacity (OR 1.26; 0.68-2.35), forced vital capacity (OR 0.84; 0.42-1.66), forced expiratory volume in one second (OR 0.70; 0.36-1.35) or lung diffusing capacity (OR 1.07; 0.58-1.97).

CONCLUSION: In the general population, the markedly higher prevalence of breathlessness in women is related to their smaller absolute lung volumes.

Ort, förlag, år, upplaga, sidor
San Francisco, USA: Public Library of Science , 2018. Vol. 13, nr 1, artikel-id e0190876
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Lungmedicin och allergi
Identifikatorer
URN: urn:nbn:se:oru:diva-64039DOI: 10.1371/journal.pone.0190876ISI: 000419403800132PubMedID: 29304074Scopus ID: 2-s2.0-85040084358OAI: oai:DiVA.org:oru-64039DiVA, id: diva2:1173506
Forskningsfinansiär
Hjärt-LungfondenKnut och Alice Wallenbergs StiftelseVetenskapsrådetVINNOVAForte, Forskningsrådet för hälsa, arbetsliv och välfärdSvenska läkaresällskapet
Anmärkning

Funding Agencies:

Sahlgrenska University Hospital  

Swedish state 

Swedish Respiratory Society

Scientific Committee of Blekinge County Council  

Wera and Emil Cornell Foundation 

Tillgänglig från: 2018-01-12 Skapad: 2018-01-12 Senast uppdaterad: 2018-08-16Bibliografiskt granskad

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