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Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation Study
Department of Epidemiology and Public Health, University College London, London, UK.
Örebro universitet, Institutionen för medicinska vetenskaper. (Clinical Epidemiology and Biostatistics)ORCID-id: 0000-0002-2088-0530
Department of Health and Social Behavior, School of Public Health, University of Tokyo, Tokyo, Japan.
Division of International and Community Oral Health, Graduate School of Dentistry, Tohoku University, Miyagi, Japan.
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2018 (Engelska)Ingår i: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, artikel-id 5362948Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

We examined correlating clinical biomarkers for the physical aspect of frailty among community-dwelling older adults in Japan, using Japanese Gerontological Evaluation Study (JAGES). We used information from the JAGES participants (N = 3,128) who also participated in the community health screening in 2010. We grouped participants' response to the Study of Osteoporotic Fracture (SOF) Frailty Index into robust (=0), intermediate frail (=1), and frail (=2+) ones to indicate physical aspect of frailty. Independent of sex and age, results from multinomial logistic regression showed above normal albumin and below normal HDL and haemoglobin levels were positively associated with intermediate frail (RRR = 1.99, 95% CI = 1.22-3.23; RRR = 1.36, 95% CI = 1.33-1.39; RRR = 1.36, 95% CI = 1.23-1.51, resp.) and frail cases (RRR = 2.27, 95% CI = 1.91-2.70; RRR = 1.59, 95% CI = 1.51-1.68; RRR = 1.40, 95% CI = 1.28-1.52, resp.). Limited to women, above normal Hb1Ac level was similarly associated with intermediate frail and frail cases (RRR = 1.18, 95% CI = 1.02, 1.38; RRR = 2.56, 95% CI = 2.23-2.95, resp.). Use of relevant clinical biomarkers can help in assessment of older adults' physical aspect of frailty.
Ort, förlag, år, upplaga, sidor
Hindawi Publishing Corporation, 2018. artikel-id 5362948
Nationell ämneskategori
Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)
Identifikatorer
URN: urn:nbn:se:oru:diva-64827DOI: 10.1155/2018/5362948ISI: 000422965600001Scopus ID: 2-s2.0-85041725243OAI: oai:DiVA.org:oru-64827DiVA, id: diva2:1180579
Anmärkning

Funding Agencies:

UK Economic and Social Research Council (ESRC)  ES/J019119/1 

Research Committee of Orebro County Council  OLL-346981 

MEXT (Ministry of Education, Culture, Sports, Science and Technology, Japan) Supported Program for the Strategic Research Foundation at Private Universities  

JSPS (Japan Society for the Promotion of Science) KAKENHI  JP22330172  JP22390400  JP23243070  JP23590786  JP23790710  JP24390469  JP24530698  JP24683018  JP25253052  JP25870573  JP25870881 

Health Labour Sciences Research Grants from the Japan Ministry of Health, Labour and Welfare  H22-Choju-Shitei-008  H24-Junkanki[Seishu]-Ippan-007  H24-Chikyukibo-Ippan-009  H24-Choju-Wakate-009  H25-Kenki-Wakate-015  H26-Irryo-Shitei-003[Fukkou]  H25-Choju-Ippan-003  H26-Choju-Ippan-006 

Research and Development Grants for Longevity Science from AMED (Japan Agency for Medical Research and Development)  

National Centre for Geriatrics and Gerontology, Japan  24-17  24-23 

Tillgänglig från: 2018-02-06 Skapad: 2018-02-06 Senast uppdaterad: 2023-12-08Bibliografiskt granskad

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Hiyoshi, Ayako

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BioMed Research International
Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

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Totalt: 327 träffar
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