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Alzheimer’s Disease and Occupational Exposures: A Systematic Literature Review and Meta-Analyses
Örebro universitet, Institutionen för medicinska vetenskaper. Department of Occupational and Environmental Medicine, Örebro University, Sweden.ORCID-id: 0000-0002-4192-8273
Örebro universitet, Handelshögskolan vid Örebro Universitet. Institute of Environmental Medicine, Karolinska Institute, Solna, Sweden.
2018 (Engelska)Ingår i: Alzheimer's Disease & Treatment, Open Access ebooks , 2018Kapitel i bok, del av antologi (Refereegranskat)
Abstract [en]

Six systematic literature reviews together with meta-analyses have been published on the associations between Alzheimer’s disease and occupational risk factors. Our meta-analyses were based only on studies fulfilling good standards of scientific quality. We scrutinized the 54 relevant original publications found using a checklist proposed by the MOOSE-group together with a new elaborated protocol. Thus our results are not hampered by bias from studies of lower scientific quality. Thirty publications fulfilled good scientific standards and were thus used in our meta-analyses. Exposures to electromagnetic fields were concerned in 12 publications. The weighted relative risk estimate was 1.35 (95% confidence interval: 1.08-1.70). Exposure to pesticides or other chemicals resulted in the statistically significant relative risk 1.5 while exposure to metals involved no increase of risk. A high degree of work complexity (especially in relation to people) and long education were both protective against Alzheimer’s disease. Based on ten studies the weighted relative risk was 0.47 (95% CI: 0.35-0.63). Both work-related risk factors and protective factors are discussed in relation to possible pathophysiological mechanisms.

Ort, förlag, år, upplaga, sidor
Open Access ebooks , 2018.
Nyckelord [en]
Epidemiology; Electromagnetic fields; Pesticides; Chemicals, Metals; Work complexity; Education.
Nationell ämneskategori
Medicin och hälsovetenskap Neurologi Arbetsmedicin och miljömedicin
Identifikatorer
URN: urn:nbn:se:oru:diva-70399ISBN: 978-93-87500-26-6 (digital)OAI: oai:DiVA.org:oru-70399DiVA, id: diva2:1267133
Tillgänglig från: 2018-11-30 Skapad: 2018-11-30 Senast uppdaterad: 2018-12-05Bibliografiskt granskad

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http://openaccessebooks.com/alzheimers-disease-treatment/alzheimers-disease-and-occupational-exposures-a-systematic-literature-review-and-meta-analyses.pdf

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Gunnarsson, Lars-GunnarBodin, Lennart

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Gunnarsson, Lars-GunnarBodin, Lennart
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Institutionen för medicinska vetenskaperHandelshögskolan vid Örebro Universitet
Medicin och hälsovetenskapNeurologiArbetsmedicin och miljömedicin

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