oru.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer's disease: the OmegAD study
Department of Neurobiology, Caring Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.ORCID-id: 0000-0001-6863-6679
Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Department of Public Health and Caring Sciences, Uppsala University Hospital, Uppsala, Sweden; Division of Clinical Nutrition and Metabolism, Uppsala University Hospital, Uppsala, Sweden.
Department of Public Health and Caring Sciences, Uppsala University Hospital, Uppsala, Sweden; Geriatrics, Uppsala University Hospital, Uppsala, Sweden.
Visa övriga samt affilieringar
2014 (Engelska)Ingår i: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 275, nr 4, s. 428-436Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVE: Little is known about the transfer of essential fatty acids (FAs) across the human blood-brain barrier (BBB) in adulthood. In this study, we investigated whether oral supplementation with omega-3 (n-3) FAs would change the FA profile of the cerebrospinal fluid (CSF).

METHODS: A total of 33 patients (18 receiving the n-3 FA supplement and 15 receiving placebo) were included in the study. These patients were participants in the double-blind, placebo-controlled randomized OmegAD study in which 204 patients with mild Alzheimer's disease (AD) received 2.3 g n-3 FA [high in docosahexaenoic acid (DHA)] or placebo daily for 6 months. CSF FA levels were related to changes in plasma FA and to CSF biomarkers of AD and inflammation.

RESULTS: At 6 months, the n-3 FA supplement group displayed significant increases in CSF (and plasma) eicosapentaenoic acid (EPA), DHA and total n-3 FA levels (P < 0.01), whereas no changes were observed in the placebo group. Changes in CSF and plasma levels of EPA and n-3 docosapentaenoic acid were strongly correlated, in contrast to those of DHA. Changes in DHA levels in CSF were inversely correlated with CSF levels of total and phosphorylated tau, and directly correlated with soluble interleukin-1 receptor type II. Thus, the more DHA increased in CSF, the greater the change in CSF AD/inflammatory biomarkers.

CONCLUSIONS: Oral supplementation with n-3 FAs conferred changes in the n-3 FA profile in CSF, suggesting transfer of these FAs across the BBB in adults.

Ort, förlag, år, upplaga, sidor
Blackwell Publishing, 2014. Vol. 275, nr 4, s. 428-436
Nyckelord [en]
Alzheimer's disease, cerebrospinal fluid, docosahexaenoic acid, eicosapentaenoic acid, omega-3 fatty acids
Nationell ämneskategori
Neurologi
Identifikatorer
URN: urn:nbn:se:oru:diva-74152DOI: 10.1111/joim.12166ISI: 000333310700009PubMedID: 24410954Scopus ID: 2-s2.0-84897024194OAI: oai:DiVA.org:oru-74152DiVA, id: diva2:1314548
Forskningsfinansiär
Stockholms läns landstingKarolinska Institutets ForskningsstiftelseDemensförbundetStiftelsen Svensk Näringsforskning
Anmärkning

Funding Agencies:

Capio

Gamla Tjänarinnor  

Swedish Alzheimer Foundation  

Odd Fellow Sweden 

Gun och Bertil Stohnes Foundation  

Swedish Society of Physicians  

Lion's Sweden  

Pronova Biocare A/S, Lysaker, Norway  

Tillgänglig från: 2019-05-09 Skapad: 2019-05-09 Senast uppdaterad: 2019-06-18Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Personposter BETA

Freund-Levi, Yvonne

Sök vidare i DiVA

Av författaren/redaktören
Freund-Levi, Yvonne
I samma tidskrift
Journal of Internal Medicine
Neurologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 49 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf