oru.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Trace level analyses of selected perfluoroalkyl substancesin food: Method development and validation
Örebro universitet, Institutionen för naturvetenskap och teknik.
2019 (Engelska)Självständigt arbete på avancerad nivå (masterexamen), 30 poäng / 45 hpStudentuppsats (Examensarbete)
Abstract [en]

To comprise the future requirements to detect low levels of perfluoroalkane acids, includingbranched and linear perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA),and perfluorohexane sulfonic acid (PFHxS) in food items, here analytical methods fordetermination of PFOS, PFOA and PFHxS in six different food matrices (cow milk, butter,chicken egg, chicken meat, beef, and fish) were optimized and validated. The optimizedmethod was based on alkaline digestion and solid-liquid extraction using acetonitrile,followed by solid phase extraction (SPE) using a weak anion exchange cartridge as clean-up.In the case of milk and egg samples, an additional clean-up with graphitized carbon (ENVICarb)was applied. The separation was performed on an ultra-performance liquidchromatograph (UPLC) in negative electrospray ionization mode (MS/MS). The methodshowed an effective way to eliminate taurodeoxycholic acid (TDC), a bile acid that is anendogenous interference compound in egg sample causing ionization suppression duringelectrospray ionization. Validation was performed and resulted in recoveries for the targetanalytes at an acceptable level >70%, the limits of quantification (LOQs) in all matrices were3.1, 3.4, 4.9 pg/g for PFHxS, PFOA, and L-PFOS, respectively. The optimized method wassuccessfully applied to 53 food samples from the Swedish market (n=18) and food samplesprovided by 11 countries through the United Nations Environment Programme project, GlobalMonitoring Plan 2 on Persistent Organic Pollutants (UNEP/GMP2) (n=35). PFOS and PFOAwere detected in all samples, and PFHxS was detected in 80% of the samples. With thismethod, concentrations in the low pg/g range in food samples were quantified including thebranched PFOS isomers. This method can be applied to enforce potential future limit valuesfor PFOS and PFOA as discussed based on the recent European Food Safety Authority(EFSA) report.Further method optimization and validation is still needed for foods of plant origin such asvegetables, flour, nuts and bread.

Ort, förlag, år, upplaga, sidor
2019. , s. 34
Nationell ämneskategori
Kemi
Identifikatorer
URN: urn:nbn:se:oru:diva-77010OAI: oai:DiVA.org:oru-77010DiVA, id: diva2:1357624
Ämne / kurs
Kemi
Handledare
Examinatorer
Tillgänglig från: 2019-10-04 Skapad: 2019-10-04 Senast uppdaterad: 2019-10-04Bibliografiskt granskad

Open Access i DiVA

Trace level analyses of selected perfluoroalkyl substances in food: Method development and validation(2756 kB)32 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 2756 kBChecksumma SHA-512
5b8344b21cdef345ddb0b7cdc94a8d0a73197fdcd15386d8011e4ebff3685c67a6d9ee415d0e2bc127031f38d896aa62a9fdd9b0135b99b5fb18a349e612ba56
Typ fulltextMimetyp application/pdf

Av organisationen
Institutionen för naturvetenskap och teknik
Kemi

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 32 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

urn-nbn

Altmetricpoäng

urn-nbn
Totalt: 51 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf