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Coeliac disease and risk of renal disease: a general population cohort study
Örebro universitet, Institutionen för klinisk medicin.ORCID-id: 0000-0003-1024-5602
Örebro universitet, Institutionen för klinisk medicin.ORCID-id: 0000-0001-6328-5494
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2006 (Engelska)Ingår i: Nephrology, Dialysis and Transplantation, ISSN 0931-0509, E-ISSN 1460-2385, Vol. 21, nr 7, s. 1809-1815Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND:

Coeliac disease (CD) may be a risk factor for renal disease.

METHODS:

We investigated the risk of any form of glomerulonephritis (GN) (acute, chronic and non-specified), chronic glomerulonephritis (CGN) and renal replacement therapy including dialysis treatment and kidney transplantation (KT) in patients with CD in a general population-based cohort study. We used Cox regression to assess the risk of renal disease in 14,336 patients who had received a diagnosis of CD (1964-2003) and 69,875 reference individuals matched for age, calendar year, sex and county. Patients were identified using the Swedish Hospital Discharge Registry. Follow-up began 1 year after study entry.

RESULTS:

CD was associated with an increased risk of any form of GN (hazard ratio (HR) = 1.64; 95% confidence intervals (CI) = 1.01-2.66; P = 0.046; 89 events), CGN (HR = 2.65; 95% CI = 1.34-5.24; P = 0.005; 39 events), dialysis (HR = 3.48; 95% CI = 2.26-5.37; P < 0.001; 102 positive events) and KT (HR = 3.15; 95% CI = 1.29-7.71; P = 0.012; 22 events).

CONCLUSION:

We suggest that immune characteristics associated with CD increase the risk of chronic renal disease. Individuals with CD may also be at a moderately increased risk of any form of GN.

Ort, förlag, år, upplaga, sidor
2006. Vol. 21, nr 7, s. 1809-1815
Nyckelord [en]
Adolescent, Adult, Celiac Disease/*complications/*diagnosis, Child, Child; Preschool, Cohort Studies, Female, Glomerulonephritis/metabolism, Humans, Infant, Infant; Newborn, Kidney Diseases/*complications/*diagnosis, Kidney Transplantation, Male, Middle Aged, Proportional Hazards Models, Risk, Risk Factors
Nationell ämneskategori
Medicin och hälsovetenskap Klinisk medicin Urologi och njurmedicin
Forskningsämne
Invärtesmedicin
Identifikatorer
URN: urn:nbn:se:oru:diva-3503DOI: 10.1093/ndt/gfl117PubMedID: 16574681OAI: oai:DiVA.org:oru-3503DiVA, id: diva2:137800
Tillgänglig från: 2008-12-08 Skapad: 2008-12-08 Senast uppdaterad: 2017-12-14Bibliografiskt granskad

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Förlagets fulltextPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16574681&dopt=Citation

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Ludvigsson, Jonas F.Montgomery, Scott M.

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Ludvigsson, Jonas F.Montgomery, Scott M.
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Nephrology, Dialysis and Transplantation
Medicin och hälsovetenskapKlinisk medicinUrologi och njurmedicin

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