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Duration of the pushing phase of labor is inversely associated with expression of TNF, IL6, IGF1 and IGF2 in human placenta
Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län. Department of Pediatrics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.ORCID-id: 0000-0002-5292-4913
Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län.
Örebro universitet, Institutionen för medicinska vetenskaper. Clinical Epidemiology Division, Department of Medicine, Karolinska Institutet, Solna, Sweden; Department of Epidemiology and Public Health, University College London, London, UK. (Clinical Epidemiology and Biostatistics)ORCID-id: 0000-0001-6328-5494
2022 (Engelska)Ingår i: The Journal of Maternal-Fetal & Neonatal Medicine, ISSN 1476-7058, E-ISSN 1476-4954, Vol. 35, nr 25, s. 6476-6482Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: Gene expression in placenta differs between vaginal and cesarean deliveries, but the influence of the duration of labor on placental gene expression is incompletely known. Our aim was to investigate associations between duration of labor and expression of some genes involved in growth or inflammation in human placental tissue.

Methods: Placenta samples (n = 126) were collected after an uncomplicated, singleton pregnancy and term vaginal delivery at orebro University Hospital, Sweden. Duration of labor was recorded by the midwife in the delivery room. The expression of the following genes was analyzed by RT-qPCR: tumor necrosis factor (TNF), interleukin-6 (IL6), C-X-C motif chemokine ligand 8, toll-like receptor (TLR) 2, TLR4, insulin receptor, insulin-like growth factor (IGF) 1, IGF2, leptin, hepatocyte growth factor (HGF) and HGF receptor (MET). Multivariable linear regression models were used for the evaluation of associations with labor duration adjusting for potential confounding factors. The Benjamini-Hoschberg method was used to correct for multiple testing.

Results: The expression of TNF, IL6, IGF1 and IGF2 was inversely associated with the duration of the pushing phase of labor (B coefficients (95% confidence interval) = -0.150 (-0.277 to -0.023), -0.159 (-0.289 to -0.029), -0.099 (-0.176 to -0.021), and -0.081 (-0.145 to -0.017), respectively).

Conclusions: Longer duration of pushing is associated with downregulation of the expression of genes in placenta from vaginal deliveries. Future research on gene expression in labored placenta should take into account associations with labor duration and especially the pushing phase. Potential impact of these associations on the mother, the fetus and the new-born infant should also be explored.

Ort, förlag, år, upplaga, sidor
Informa Healthcare, 2022. Vol. 35, nr 25, s. 6476-6482
Nyckelord [en]
Gene expression, insulin-like growth factors, interleukin-6, labor duration, placenta, pushing phase
Nationell ämneskategori
Medicinsk genetik och genomik
Identifikatorer
URN: urn:nbn:se:oru:diva-91667DOI: 10.1080/14767058.2021.1916459ISI: 000646787600001PubMedID: 33910460Scopus ID: 2-s2.0-85105914353OAI: oai:DiVA.org:oru-91667DiVA, id: diva2:1553275
Tillgänglig från: 2021-05-07 Skapad: 2021-05-07 Senast uppdaterad: 2025-02-10Bibliografiskt granskad

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Lodefalk, MariaAllbrand, MarianneMontgomery, Scott

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