Till Örebro universitet

oru.seÖrebro universitets publikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
National infection control program has no effect on postoperative infections after total hip arthroplasty
Örebro universitet, Institutionen för medicinska vetenskaper. Department of Orthopedics.
Department of Orthopedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Swedish Hip Arthroplasty Register, Centre of Registers, Västra Götalandsregionen, Gothenburg.
Örebro universitet, Institutionen för medicinska vetenskaper. Department of Orthopedics.
Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm.
Visa övriga samt affilieringar
(Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
Nationell ämneskategori
Kirurgi
Identifikatorer
URN: urn:nbn:se:oru:diva-94137OAI: oai:DiVA.org:oru-94137DiVA, id: diva2:1591672
Tillgänglig från: 2021-09-07 Skapad: 2021-09-07 Senast uppdaterad: 2021-09-28Bibliografiskt granskad
Ingår i avhandling
1. Prosthetic Joint Infection of the Hip: Cause and Effect
Öppna denna publikation i ny flik eller fönster >>Prosthetic Joint Infection of the Hip: Cause and Effect
2021 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Every year, 18 000 patients in Sweden and more than 1 million worldwide undergo total hip arthroplasty (THA). The operation is of great benefit to patients, but is associated with several complications. Prosthetic joint infections (PJIs) are among the most common complications, and can be devastating in terms of suffering for the patient and cost for the healthcare provider. The aim of this thesis was to investigate different aspects of PJIs in order to gain a better understanding of the causes and effects of infection. 

Four studies were conducted covering genomic analysis of the causative organism, identification of risk factors for failure of treatment, evaluation of a national infection control program aimed at reducing the burden of infections (PRISS: Prosthesis-related infections shall be stopped), and examination of the long-term impact of a PJI on the patient’s health through patient-reported measurement questionnaires.

The main findings were as follows. Commensal bacteria such as Cutibacterium avidum have the potential to cause PJIs, and should be specially accounted for when performing hip surgery with an anterior approach. S. aureus is both a commensal and a pathogen with invasive capacity, and the commensal strains do not differ from the PJI strains regarding prevalence of virulence genes and clonal complexes. The genomic traits of pathogens had no impact on treatment success or eradication of infection in S. aureus PJIs The long-term effects of a PJI in the hip include increased mortality, lower quality of life, and decreased hip function. The incidence of PJIs was higher following the PRISS project. Increasing risk factors contributing to PJI explain the increasing incidence of PJI after primary THA.

In conclusion, PJIs of the hip have multifactorial causes which are difficult to reduce, and long-term effects are severe.

Ort, förlag, år, upplaga, sidor
Örebro: Örebro University, 2021. s. 98
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 246
Nyckelord
Prosthetic joint infection, infection, arthroplasty, hip, Staphylococcus aureus, Cutibacterium avidum, hip, outcome, PROM
Nationell ämneskategori
Kirurgi
Identifikatorer
urn:nbn:se:oru:diva-92269 (URN)978-91-7529-398-1 (ISBN)
Disputation
2021-10-01, Örebro universitet, Campus USÖ, hörsal C1, Södra Grev Rosengatan 32, Örebro, 09:00 (Svenska)
Opponent
Handledare
Tillgänglig från: 2021-06-09 Skapad: 2021-06-09 Senast uppdaterad: 2023-08-29Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Person

Wildeman, PeterWretenberg, PerSöderquist, Bo

Sök vidare i DiVA

Av författaren/redaktören
Wildeman, PeterWretenberg, PerSöderquist, Bo
Av organisationen
Institutionen för medicinska vetenskaper
Kirurgi

Sök vidare utanför DiVA

GoogleGoogle Scholar

urn-nbn

Altmetricpoäng

urn-nbn
Totalt: 259 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf