oru.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Experts do not agree when to treat retinopathy of prematurity based on plus disease
Department of Ophthalmology, Copenhagen University Hospital, Glostrup Hospital, Glostrup, Denmark.
Departmant of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
Department of Optometry and Visual Science, City University, London, UK .
Örebro universitet, Institutionen för hälsovetenskap och medicin. Department of Ophthalmology, Örebro University Hospital, Örebro, Sweden.
Visa övriga samt affilieringar
2012 (Engelska)Ingår i: British Journal of Ophthalmology, ISSN 0007-1161, E-ISSN 1468-2079, Vol. 96, nr 4, s. 549-553Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives: To investigate inter-reader agreement on five severity levels of central vascular changes (none, mild, moderate, severe pre-plus disease, plus disease) and aggressive posterior retinopathy of prematurity (ROP), and to see whether an unintended shift in indication for treatment occurred.

Methods: Four international ROP readers participated. Before the grading of the photographs, the readers were informed that a high proportion of advanced ROP cases were included. In total, 243 photographs/948 quadrants were available from 136 infants. As a standard series of photographs was available, grading was performed under optimised conditions.

Results: The four readers agreed on the quadrant scores of only 70 (7.38%) of the 948 quadrants-that is, on 1, 5, 15, 4 and 45 quadrants for scores 0, 1, 2, 3 and 4, respectively. The mean scores differed systematically between the readers (permutation test, p<0.0001). Agreement on presence of aggressive posterior ROP from all four readers was not obtained for any of the photographs. Readers scored plus disease in at least two quadrants in 95.5% of the eyes for which treatment was indicated. All four readers agreed on the scoring of indication for treatment for 195 eyes (80.2%); however, treatment was only recommended in 18 (7.4%) eyes. One reader was found to differ systematically from the others in indicating treatment (Rasch analysis; p=0.0001). Finally, a significant shift in indication for treatment occurred between birth period 2000-2002 and 2003-2006 (Mann-Whitney rank sum test, p<0.001).

Conclusions: Inter-reader agreement on central vascular changes is poor, especially when based on more than two rating categories. The subjective nature of diagnosing such vascular changes possibly resulted in earlier treatment of preterm infants in Denmark over the entire study period (1997-2006). The recent increased incidence of treated infants in Denmark is, at least in part, explained by a significant shift in indication for treatment.

Ort, förlag, år, upplaga, sidor
London, United Kingdom: B M J Publishing Group , 2012. Vol. 96, nr 4, s. 549-553
Nationell ämneskategori
Medicin och hälsovetenskap Oftalmologi
Forskningsämne
Medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-22623DOI: 10.1136/bjophthalmol-2011-300573ISI: 000301938700019PubMedID: 22174097Scopus ID: 2-s2.0-84858340878OAI: oai:DiVA.org:oru-22623DiVA, id: diva2:517233
Anmärkning

Funding Agencies:

Danish Eye Health Society 

Bagenkop Nielsens Myopi- and Eye Foundation 

VELUX Foundation

Aase and Ejnar Danielsens Foundation

Dagmar Marshalls Foundation

Direktor Jacob Madsen and Hustru Olga Madsens Foundation 

P. A. Messerschmidt and Hustrus Foundation 

Tillgänglig från: 2012-04-23 Skapad: 2012-04-23 Senast uppdaterad: 2017-12-07Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Personposter BETA

Crafoord, Sven

Sök vidare i DiVA

Av författaren/redaktören
Crafoord, Sven
Av organisationen
Institutionen för hälsovetenskap och medicin
I samma tidskrift
British Journal of Ophthalmology
Medicin och hälsovetenskapOftalmologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 439 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf