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Chemical and bioanalytical characterisation of PAHs in risk assessment of remediated PAH-contaminated soils
Örebro universitet, Institutionen för naturvetenskap och teknik. (MTM)
Örebro universitet, Institutionen för naturvetenskap och teknik. (MTM)ORCID-id: 0000-0003-4128-8226
Örebro universitet, Akademin för naturvetenskap och teknik. (MTM)
Örebro universitet, Institutionen för naturvetenskap och teknik. (MTM)ORCID-id: 0000-0001-6217-8857
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2013 (Engelska)Ingår i: Environmental science and pollution research international, ISSN 0944-1344, E-ISSN 1614-7499, Vol. 20, nr 12, s. 8511-8520Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Polycyclic aromatic hydrocarbons (PAHs) are common contaminants in soil at former industrial areas; and in Sweden, some of the most contaminated sites are being remediated. Generic guideline values for soil use after so-called successful remediation actions of PAH-contaminated soil are based on the 16 EPA priority pollutants, which only constitute a small part of the complex cocktail of toxicants in many contaminated soils. The aim of the study was to elucidate if the actual toxicological risks of soil samples from successful remediation projects could be reflected by chemical determination of these PAHs. We compared chemical analysis (GC-MS) and bioassay analysis (H4IIE-luc) of a number of remediated PAH-contaminated soils. The H4IIE-luc bioassay is an aryl hydrocarbon (Ah) receptor-based assay that detects compounds that activate the Ah receptor, one important mechanism for PAH toxicity. Comparison of the results showed that the bioassay-determined toxicity in the remediated soil samples could only be explained to a minor extent by the concentrations of the 16 priority PAHs. The current risk assessment method for PAH-contaminated soil in use in Sweden along with other countries, based on chemical analysis of selected PAHs, is missing toxicologically relevant PAHs and other similar substances. It is therefore reasonable to include bioassays in risk assessment and in the classification of remediated PAH-contaminated soils. This could minimise environmental and human health risks and enable greater safety in subsequent reuse of remediated soils.

Ort, förlag, år, upplaga, sidor
2013. Vol. 20, nr 12, s. 8511-8520
Nationell ämneskategori
Naturvetenskap
Forskningsämne
Biologi; Miljökemi; Miljövetenskap
Identifikatorer
URN: urn:nbn:se:oru:diva-29084DOI: 10.1007/s11356-013-1787-6ISI: 000327498600022OAI: oai:DiVA.org:oru-29084DiVA, id: diva2:622275
Forskningsfinansiär
KK-stiftelsenNaturvårdsverketTillgänglig från: 2013-05-21 Skapad: 2013-05-21 Senast uppdaterad: 2017-12-06Bibliografiskt granskad
Ingår i avhandling
1. Chemical and bioanalytical characterisation of PAH-contaminated soils: identification, availability and mixture toxicity of AhR agonists
Öppna denna publikation i ny flik eller fönster >>Chemical and bioanalytical characterisation of PAH-contaminated soils: identification, availability and mixture toxicity of AhR agonists
2013 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Contaminated soils are a worldwide problem. Polycyclic aromatic hydrocarbons (PAHs) are common contaminants in soil at former industrial areas, especially at old gasworks sites, gas stations and former wood impregnation facilities. Risk assessments of PAHs in contaminated soils are usually based on chemical analysis of a small number of individual PAHs, which only constitute a small part of the complex cocktail of hundreds of PAHs and other related polycyclic aromatic compounds (PACs) in the soils. Generally, the mixture composition of PAH-contaminated soils is rarely known and the mechanisms of toxicity and interactions between the pollutants are far from fully understood.

The main objective of this thesis was to characterize remediated PAHcontaminated soils by use of a chemical and bioanalytical approach. Bioassay specific relative potency (REP) values for 38 PAHs and related PACs were developed in the sensitive H4IIE-luc bioassay and used in massbalance analysis of remediated PAH contaminated soils, to assess the contribution of chemically quantified compounds to the overall aryl hydrocarbon receptor (AhR)-mediated activity observed in the H4IIE-luc bioassay. Mixtures studies showed additive AhR-mediated effects of PACs, including PAHs, oxy PAHs, methylated PAHs and azaarenes, in the bioassay, which supports the use of REP values in risk assessment. The results from the chemical and bioassay analysis showed that PAH-contaminated soils contained a large fraction of AhR activating compounds whose effect could not be explained by chemical analysis of the 16 priority PAHs. Further chemical identification and biological studies are necessary to determine whether these unknown substances pose a risk to human health or the environment. Results presented in this thesis are an important step in the development of AhR-based bioassay analysis and risk assessment of complex PAH-contaminated samples.

Ort, förlag, år, upplaga, sidor
Örebro: Örebro universitet, 2013. s. 60
Serie
Örebro Studies in Chemistry, ISSN 1651-4270 ; 13
Nyckelord
Polycyclic aromatic compounds, Soil, Risk assessment, Mixture studies, AhR-mediated activity, REPs, GC/MS, H4IIE-luc bioassay
Nationell ämneskategori
Kemi
Forskningsämne
Kemi
Identifikatorer
urn:nbn:se:oru:diva-30070 (URN)978-91-7668-961-5 (ISBN)
Disputation
2013-09-27, Hörsalen, Billbergska huset, Örebro universitet, Fakultetsgatan 1, 701 82 Örebro, 10:00 (Svenska)
Opponent
Handledare
Forskningsfinansiär
NaturvårdsverketKK-stiftelsen
Anmärkning

Other funders: Sparbanksstiftelsen Nya and Ångpanneföreningen

Tillgänglig från: 2013-07-30 Skapad: 2013-07-30 Senast uppdaterad: 2017-10-17Bibliografiskt granskad

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Larsson, MariaHagberg, JessikaRotander, Annavan Bavel, BertEngwall, Magnus

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Larsson, MariaHagberg, JessikaRotander, Annavan Bavel, BertEngwall, Magnus
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Environmental science and pollution research international
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