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Prevalence and typing of Propionibacterium acnes in prostate tissue obtained from men with prostate cancer and from health controls
Örebro universitet, Institutionen för hälsovetenskap och medicin.
Örebro universitet, Institutionen för hälsovetenskap och medicin.
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(Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
Nationell ämneskategori
Urologi och njurmedicin
Forskningsämne
Medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-30106OAI: oai:DiVA.org:oru-30106DiVA, id: diva2:638767
Tillgänglig från: 2013-08-02 Skapad: 2013-08-02 Senast uppdaterad: 2017-10-17Bibliografiskt granskad
Ingår i avhandling
1. Infection induced chronic inflammation and it's association with prostate cancer initiation and progression
Öppna denna publikation i ny flik eller fönster >>Infection induced chronic inflammation and it's association with prostate cancer initiation and progression
2013 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

An association between cancer development and inflammation has long been suggested. Approximately 20% of all human cancers in adults are assumed to result from chronic inflammation. The aim of this thesis was to investigate if infection-induced chronic inflammation plays a role in prostate carcinogenesis.

Our results revealed a greater infiltration of the bacterium Propionibacterium acnes in the prostate tissue obtained from men with prostate cancer compared to men without any histological evidence of the disease. These findings indicate that prostate cancer could potentially be included in the list of cancers with an infectious etiology.

Further, we investigated whether chronic inflammation has a role in disease progression. Our results demonstrated that men with lethal prostate cancer had pronounced infiltration of immune cells with suppressive function of the anti-tumor immune response compared to men with a more indolent prostate cancer.

Confirmation of our results may open up avenues for targeted prostate cancer treatment by offering men with chronic inflammation alternative therapies such as anti-inflammatory drugs. If the involvement of P. acnes in prostate cancer development is replicated in other studies, vaccination therapies may be feasible. To further individualize prostate cancer therapy, bolstering the anti-tumor immune response in order to reduce tumor progression may be determined to be advantageous for some patients.

Ort, förlag, år, upplaga, sidor
Örebro: Örebro universitet, 2013. s. 65
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 86
Nyckelord
Prostate cancer, chronic inflammation, CD4 helper T cells, CD8 cytotoxic T cells, regulatory T cells, Propionibacterium acnes
Nationell ämneskategori
Medicin och hälsovetenskap
Forskningsämne
Medicin
Identifikatorer
urn:nbn:se:oru:diva-28466 (URN)978-91-7668-920-2 (ISBN)
Disputation
2013-05-31, Wilandersalen, Universitetssjukhuset i Örebro, Södra Grev Rosengatan 18, 703 62 Örebro, 09:00 (Svenska)
Opponent
Handledare
Tillgänglig från: 2013-03-25 Skapad: 2013-03-25 Senast uppdaterad: 2017-10-17Bibliografiskt granskad

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Davidsson, SabinaUnemo, MagnusAndersson, Swen-OlofAndrén, OveSöderquist, Bo

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Davidsson, SabinaUnemo, MagnusAndersson, Swen-OlofAndrén, OveSöderquist, Bo
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Urologi och njurmedicin

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