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Coffee consumption and risk of localized, advanced and fatal prostate cancer: a population-based prospective study
Unit of Nutritional Epidemiology, Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Unit of Nutritional Epidemiology, Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Örebro universitet, Institutionen för hälsovetenskap och medicin. Department of Urology, Örebro University Hospital, Örebro, Sweden.
Örebro universitet, Institutionen för hälsovetenskap och medicin. Region Örebro län. Department of Urology, Örebro University Hospital, Örebro, Sweden.
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2013 (Engelska)Ingår i: Annals of Oncology, ISSN 0923-7534, E-ISSN 1569-8041, Vol. 24, nr 7, s. 1912-1918Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: The epidemiological evidence on possible relationships between coffee consumption and prostate cancer (PCa) risk by subtype of the disease (localized, advanced) and fatal PCa risk is limited.

Materials and methods: A population-based cohort of 44 613 Swedish men aged 45-79 years was followed up from January 1998 through December 2010 for incidence of localized (n = 2368), advanced (n = 918) and fatal (n = 515) PCa. We assessed the associations between coffee consumption and localized, advanced and fatal PCa risk using competing-risk regressions. We examined possible effect modification by body mass index (BMI).

Results: For localized PCa, each one cup increase in daily coffee consumption was associated with a 3% reduced risk [sub-hazard ratio (SHR) = 0.97, 95% confidence interval (CI) = 0.95-0.99]. For advanced and fatal PCa, we found a non-significant inverse association; each one cup increase was associated with a 2% reduced risk of advanced [SHR (95% CI) = 0.98 (0.95-1.02)] and fatal PCa [SHR (95% CI) = 0.98 (0.93-1.03)]. We observed evidence of effect modification by BMI for localized PCa (P-interaction = 0.03); the inverse association was stronger among overweight and obese men (BMI >= 25 kg/m(2)) compared with normal-weight men (BMI < 25 kg/m(2)).

Conclusions: We observed a clear inverse association between coffee consumption and risk of localized PCa, especially among overweight and obese men.

Ort, förlag, år, upplaga, sidor
2013. Vol. 24, nr 7, s. 1912-1918
Nyckelord [en]
coffee, epidemiology, prospective cohort study, prostate cancer
Nationell ämneskategori
Medicin och hälsovetenskap
Forskningsämne
Medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-30237DOI: 10.1093/annonc/mdt105ISI: 000321881600030OAI: oai:DiVA.org:oru-30237DiVA, id: diva2:641250
Tillgänglig från: 2013-08-16 Skapad: 2013-08-16 Senast uppdaterad: 2018-05-21Bibliografiskt granskad

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Andersson, Swen-OlofAndrén, OveJohansson, Jan-Erik

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Institutionen för hälsovetenskap och medicinRegion Örebro län
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Annals of Oncology
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