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Polymorphism in the retinoic acid metabolizing enzyme CYP26B1 and the development of Crohn's disease
Örebro universitet, Institutionen för hälsovetenskap och medicin.ORCID-id: 0000-0002-9826-0462
Örebro universitet, Institutionen för hälsovetenskap och medicin.
Örebro University Hospital, Örebro, Sweden.
Örebro universitet, Institutionen för hälsovetenskap och medicin.
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2013 (Engelska)Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, nr 8, s. e72739-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Several studies suggest that Vitamin A may be involved in the pathogenesis of inflammatory bowel disease (IBD), but the mechanism is still unknown. Cytochrome P450 26 B1 (CYP26B1) is involved in the degradation of retinoic acid and the polymorphism rs2241057 has an elevated catabolic function of retinoic acid, why we hypothesized that the rs2241057 polymorphism may affect the risk of Crohn's disease (CD) and Ulcerative Colitis (UC). DNA from 1378 IBD patients, divided into 871 patients with CD and 507 with UC, and 1205 healthy controls collected at Örebro University Hospital and Karolinska University Hospital were analyzed for the CYP26B1 rs2241057 polymorphism with TaqMan® SNP Genotyping Assay followed by allelic discrimination analysis. A higher frequency of patients homozygous for the major (T) allele was associated with CD but not UC compared to the frequency found in healthy controls. A significant association between the major allele and non-stricturing, non-penetrating phenotype was evident for CD. However, the observed associations reached borderline significance only, after correcting for multiple testing. We suggest that homozygous carriers of the major (T) allele, relative to homozygous carriers of the minor (C) allele, of the CYP26B1 polymorphism rs2241057 may have an increased risk for the development of CD, which possibly may be due to elevated levels of retinoic acid. Our data may support the role of Vitamin A in the pathophysiology of CD, but the exact mechanisms remain to be elucidated.

Ort, förlag, år, upplaga, sidor
2013. Vol. 8, nr 8, s. e72739-
Nationell ämneskategori
Medicinsk genetik
Forskningsämne
Medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-30844DOI: 10.1371/journal.pone.0072739ISI: 000323425700188PubMedID: 23977348Scopus ID: 2-s2.0-84907505415OAI: oai:DiVA.org:oru-30844DiVA, id: diva2:649186
Forskningsfinansiär
Vetenskapsrådet
Anmärkning

Funding agency:

Örebro University 

Bengt Ihre's foundation 

Nanna Svartz' foundation 

Orebro University Hospital Research Foundation 

Orebro County Research Foundation 

Swedish Foundation for Gastrointestinal research

Tillgänglig från: 2013-09-17 Skapad: 2013-09-17 Senast uppdaterad: 2018-05-21Bibliografiskt granskad

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Fransén, KarinElmabsout, AliNyhlin, NilsWickbom, AnnaBohr, JohanTysk, CurtSirsjö, AllanHalfvarson, Jonas

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Fransén, KarinElmabsout, AliNyhlin, NilsWickbom, AnnaBohr, JohanTysk, CurtSirsjö, AllanHalfvarson, Jonas
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Institutionen för hälsovetenskap och medicinRegion Örebro länInstitutionen för läkarutbildning
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