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Electrochemotherapy - possible benefits and limitations to its use in the head and neck region
Örebro universitet, Institutionen för hälsovetenskap och medicin. Örebro University Hospital, Örebro, Sweden.
Örebro University Hospital, Örebro, Sweden.
Örebro University Hospital, Örebro, Sweden.
Örebro universitet, Institutionen för hälsovetenskap och medicin.
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2015 (Engelska)Ingår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 135, nr 1, s. 90-95Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Conclusion: Electrochemotherapy (ECT) is an efficacious treatment. It should, however, be used with some caution in the treatment of head and neck cancer.

Objectives: To assess local tumor control, safety, survival, and functional outcome after treatment of cancer in the head and neck region with ECT.

Methods: Four patients with primary T2 cancer of the oral cavity or oropharynx and one patient with a metastasis of renal cancer in the masseter muscle were treated with ECT with intratumorally administered bleomycin. Control biopsies were carried out 2 months after treatment. Postoperative radiotherapy was performed based on tumor T-stage and the depth of tumor infiltration. Serious adverse events and treatment malfunctions were recorded. The follow-up time was 24 months for the surviving patients and 20 months overall. The PSS-HN scale was used to assess the functional outcome.

Results: No local recurrence was recorded in any patient during the follow-up. However, only one patient was treated with ECT alone. There were four serious adverse events: one nearly lethal bleeding, two cases of osteoradionecrosis, and a fistula. One patient died from distant metastasis. The other patients were tumor-free both locally and overall at 24 months. The median functional outcome in all parameters was worse 1 year after treatment.

Ort, förlag, år, upplaga, sidor
Informa Healthcare, 2015. Vol. 135, nr 1, s. 90-95
Nationell ämneskategori
Oto-rino-laryngologi
Identifikatorer
URN: urn:nbn:se:oru:diva-39848DOI: 10.3109/00016489.2014.947655ISI: 000346275600013PubMedID: 25496181Scopus ID: 2-s2.0-84918592776OAI: oai:DiVA.org:oru-39848DiVA, id: diva2:772319
Anmärkning

Funding agency: Genetronics Inc., San Diego, CA, USA

Tillgänglig från: 2014-12-16 Skapad: 2014-12-16 Senast uppdaterad: 2018-06-26Bibliografiskt granskad
Ingår i avhandling
1. Curative electrochemotherapy in the head and neck area
Öppna denna publikation i ny flik eller fönster >>Curative electrochemotherapy in the head and neck area
2015 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Ort, förlag, år, upplaga, sidor
Örebro: Örebro university, 2015. s. 94
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 117
Nationell ämneskategori
Kirurgi
Forskningsämne
Kirurgi
Identifikatorer
urn:nbn:se:oru:diva-42215 (URN)978-91-7529-061-4 (ISBN)
Disputation
2015-03-06, Universitetssjukhuset, Bomanssonsalen, Södra Grev Rosengatan, Örebro, 13:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2015-01-26 Skapad: 2015-01-26 Senast uppdaterad: 2017-10-17Bibliografiskt granskad

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Landström, Fredrikvon Beckerath, MathiasLöfgren, LennartMöller, Claes

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