oru.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Stress-induced insulin resistance: recent developments
Karolinska Institute, CLINTEC, Karolinska University Hospital, Huddinge; Centre for Gastrointestinal Disease, Ersta Hospital, Stockholm; Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Karolinska Institute, CLINTEC, Karolinska University Hospital, Huddinge; Centre for Gastrointestinal Disease, Ersta Hospital, Stockholm.
Karolinska Institute, CLINTEC, Karolinska University Hospital, Huddinge; Centre for Gastrointestinal Disease, Ersta Hospital, Stockholm.
Karolinska Institute, CLINTEC, Karolinska University Hospital, Huddinge; Centre for Gastrointestinal Disease, Ersta Hospital, Stockholm.ORCID-id: 0000-0003-2636-4745
2007 (Engelska)Ingår i: Current opinion in clinical nutrition and metabolic care, ISSN 1363-1950, E-ISSN 1473-6519, Vol. 10, nr 2, s. 181-6Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Purpose of review: Interest in stress-induced insulin resistance has increased during the past 5 years. Relevant clinical and mechanistic investigations during the past year will be reviewed.

Recent findings: Recent trials of intensive insulin therapy in intensive care units have brought attention to a high incidence of hypoglycemic episodes with such treatment. The clinical relevance of such hypoglycemia has been shown to be minor, however. Furthermore, animal and in-vitro work further supports the finding that glucose control, rather than glycemia-independent effects of insulin, is the primary mechanism of action of intensive insulin therapy. In elective surgery, cohort studies show an association between intraoperative hyperglycemia and postoperative morbidity. Beneficial effects of preoperative oral carbohydrate treatment on immunocompetence and cardiac contractility have been demonstrated. Laparoscopic segmental colectomy was associated with considerably attenuated derangements in glucose metabolism compared with conventional, open surgery.

Summary: Better methods of insulin dosing and administration and glucose monitoring are warranted to further minimize the risks of intensive insulin therapy. In elective surgery, perioperative measures such as preoperative oral carbohydrate treatment and laparoscopic techniques attenuate metabolic and other physiological derangements and such methods should be integrated into perioperative care protocols to minimize morbidity and enhance recovery.

Ort, förlag, år, upplaga, sidor
Philadelphia, USA: Lippincott Williams & Wilkins, 2007. Vol. 10, nr 2, s. 181-6
Nyckelord [en]
Glucose, insulin, intensive care, morbidity, perioperative care
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:oru:diva-40362DOI: 10.1097/MCO.0b013e32801481dfISI: 000244629900010PubMedID: 17285007Scopus ID: 2-s2.0-33846856161OAI: oai:DiVA.org:oru-40362DiVA, id: diva2:777200
Tillgänglig från: 2015-01-08 Skapad: 2015-01-08 Senast uppdaterad: 2017-12-05Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Personposter BETA

Ljungqvist, Olle

Sök vidare i DiVA

Av författaren/redaktören
Ljungqvist, Olle
I samma tidskrift
Current opinion in clinical nutrition and metabolic care
Medicin och hälsovetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 462 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf