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Novel strategies to identify biomarkers in tuberculosis
Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany.
Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany; Department of Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany .
Research Institute for the Biology of Farm Animals, Genetics and Biometry, Dummerstorf, Germany.ORCID-id: 0000-0002-7173-5579
Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany.
2008 (Engelska)Ingår i: Biological chemistry (Print), ISSN 1431-6730, E-ISSN 1437-4315, Vol. 389, nr 5, s. 487-95Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The more we learn about the immune response against tuberculosis (TB) and particularly about the features which distinguish protective immunity, disease susceptibility and pathology, the better we can define biomarkers which correlate with these different stages of infection. The most widely used biomarker in TB, which without a doubt is an important component of protective immunity, is IFNgamma secreted by antigen-specific CD4 T-cells. However, the complexity of the immune response against TB makes it more than likely that additional biomarkers are required for a reliable correlate of protection. As a corollary, we assume that a set of biomarkers will be required, termed a biosignature.

Ort, förlag, år, upplaga, sidor
Berlin, Germany: Walter de Gruyter, 2008. Vol. 389, nr 5, s. 487-95
Nyckelord [en]
Antigen, biosignature, metabolomics, proteomics, T-cells, transcriptomics
Nationell ämneskategori
Bioinformatik och systembiologi
Identifikatorer
URN: urn:nbn:se:oru:diva-40729DOI: 10.1515/BC.2008.053ISI: 000255439000004PubMedID: 18953715Scopus ID: 2-s2.0-45749106709OAI: oai:DiVA.org:oru-40729DiVA, id: diva2:778563
Tillgänglig från: 2015-01-11 Skapad: 2015-01-11 Senast uppdaterad: 2018-01-30Bibliografiskt granskad

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