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Bereavement is associated with an increased risk of HPV infection and cervical cancer: an epidemiological study in Sweden
Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, sweden.
Örebro universitet, Institutionen för medicinska vetenskaper. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA. (Clinical Epidemiology and Biostatistics)ORCID-id: 0000-0002-3649-2639
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2016 (Engelska)Ingår i: Cancer Research, ISSN 0008-5472, E-ISSN 1538-7445, Vol. 76, nr 3, s. 643-651Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Grief over the loss of a family member may cause physical and mental illness, but an association between bereavement and cancer risk has not been established. Based on the Swedish National Cervical Screening Register (1969-2011) including 14,011,269 smears from 2,466,107 women, we conducted two nested case-control studies to examine the associations of bereavement (i.e., loss of a family member due to death) with abnormal cytology (390,310 first abnormal and 1,951,319 normal smears) and in situ/invasive cervical cancer (75,128 case and 375,640 control women), both individually matched on year of birth and screening adherence. Among 1,696 of the control women, we further investigated bereavement in association with HPV infection, both HPV16 and other HPV types. Bereavement was consistently associated with a 4-9% increased risk for first abnormal cytology, in situ and invasive cervical cancer (all P<0.02). The associations became stronger when multiple losses, loss of child, sibling or spouse, and loss due to unnatural cause were analyzed separately (P for trend or difference<0.0001), and for women with high screening adherence (P for difference<0.05). Among 1,696 women who had not developed cervical cancer, we further investigated the link between bereavement and HPV infection. Bereavement was associated with a 62% increased risk of HPV16 infection, high viral load, and recurrent infection, and was also more strongly associated with HPV infections designated as high-risk compared to low-risk determinants of cervical carcinogenesis. Collectively, our findings demonstrate that bereavement is associated with an increased risk of developing cervical cancer. Further, they suggest that this association may be attributed to stress-induced oncogenic HPV infections.

Ort, förlag, år, upplaga, sidor
Philadelphia, United States: American Association for Cancer Research , 2016. Vol. 76, nr 3, s. 643-651
Nationell ämneskategori
Klinisk medicin Cancer och onkologi
Forskningsämne
Onkologi
Identifikatorer
URN: urn:nbn:se:oru:diva-47205DOI: 10.1158/0008-5472.CAN-15-1788ISI: 000369084600015PubMedID: 26634926OAI: oai:DiVA.org:oru-47205DiVA, id: diva2:889217
Forskningsfinansiär
NIH (National Institute of Health), R01 CA61197-01A3
Anmärkning

Funding Agencies:

NCI at the NIH 1R01CA093378-01A1 5R01CA111720-03

Swedish National Cancer Society 4877-B03-01XAC 3436-B97-04XAA

Karolinska Institutet

Swedish Society for Medical Research

Karolinska Institutet Research Associate Award

Karolinska Institutet Distinguished Professor Award 2368/10-221

Tillgänglig från: 2015-12-22 Skapad: 2015-12-22 Senast uppdaterad: 2018-09-18Bibliografiskt granskad

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