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Prevalence and trends in adult-type hypolactasia in different age cohorts in Central Sweden diagnosed by genotyping for the adult-type hypolactasia-linked LCT -13910C > T mutation
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2007 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, Vol. 42, no 2, 165-170Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Adult-type hypolactasia (AtH) can be diagnosed by genotyping in addition to functional tests or intestinal biopsy. The aims of this study were to estimate the prevalence of AtH by genotyping and to investigate whether AtH prevalence has changed in Sweden during the 20th century. MATERIAL AND METHODS: Schoolchildren (n=690) born in 1983 and 1989, and elderly individuals (n=392) born between 1920 and 1932 were genotyped for AtH using Pyrosequencing technology. RESULTS: The overall prevalence of AtH among children was 14.1%. The majority of children (92%, n=635) were Caucasians with genotype prevalences: CC, 61 (10%); CT, 259 (41%); TT, 307 (49%). The frequency of the mutated allele q was 0.300 in this cohort. The prevalence of AtH estimated from the Hardy-Weinberg equilibrium (HWE) (q 2), was 9.0% (95% CI: 6.7-11.2%). Eight percent (n=55) of the children were non-Caucasian; genotype prevalences were CC, 36 (66%); CT, 15 (27%); TT, 4 (7%). The prevalence of AtH in these children estimated from HWE was 62.5% (95% CI: 49.7-75.3%). The elderly subjects were all Caucasians. Their genotype prevalences were: CC, 20 (5%); CT, 166 (42%); TT, 206 (53%); the frequency of the mutated allele q was 0.262 and their AtH prevalence estimated from HWE was 6.8% (95% CI: 4.3-9.2%). CONCLUSIONS: The overall prevalence of AtH in children (14%) was higher than previously thought. Among Caucasians, higher figures were seen in children than in the elderly (9% versus 6.8%). The prevalence thus seems to be increasing and this may be due to the immigration of both non-Caucasian and Caucasian groups with a higher prevalence of AtH.

National Category
Medical and Health Sciences Gastroenterology and Hepatology
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-11542 (URN)10.1080/00365520600825257 (DOI)17327935 (PubMedID)oai:DiVA.org:oru-11542 (OAI)diva2:342910 (DiVA)
Available from2010-08-11 Created:2010-08-11 Last updated:2011-04-21Bibliographically approved
In thesis
1. Lactase Persistence and Lactase Non-Persistence
Open this publication in new window or tab >>Lactase Persistence and Lactase Non-Persistence : Prevalence, influence on body fat, body height, and relation to the metabolic syndrome
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Publisher, range
Örebro: Örebro universitet, 2010. 45 p.
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 48
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-11854 (URN)978-91-7668-767-3 (ISBN)
Public defence
2010-12-15, Wilandersalen, Universitetssjukhuset Örebro, Fakultetsgatan 1, 701 82 Örebro, 09:00
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Available from2010-09-17 Created:2010-09-17 Last updated:2011-04-21Bibliographically approved

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Almon, RicardoEngfeldt, PeterTysk, CurtSjöström, MichaelNilsson, Torbjörn K.
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