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Relative Immaturity in Childhood and Attention-Deficit/Hyperactivity Disorder Symptoms From Childhood to Early Adulthood: Exploring Genetic and Environmental Overlap Across Development
Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet, Stockholm, Sweden.
University of Chicago, Chicago, USA .
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2016 (Engelska)Ingår i: Journal of the American Academy of Child and Adolescent Psychiatry, ISSN 0890-8567, E-ISSN 1527-5418, Vol. 55, nr 10, s. 886-895Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: Attention-deficit/hyperactivity disorder (ADHD) has been linked to immaturity relative to peers in childhood, yet it is unclear how such immaturity is associated with ADHD across development. This longitudinal twin study examined the genetic and environmental contributions to the association between parents' perception of their child's immaturity relative to peers (RI) in childhood and ADHD symptoms across development.

Method: 1,302 twin pairs from the Swedish Twin Study of Child and Adolescent Development were followed prospectively from childhood to early adulthood. Parent ratings of RI were collected at 8 to 9 years and parent and self-ratings of ADHD symptoms were collected at 8 to 9, 13 to 14, 16 to 17, and 19 to 20 years using the Child Behavior Checklist Attention Problems scale. In addition, ADHD symptoms corresponding to DSM criteria were used for sensitivity analysis. Analyses were conducted using longitudinal structural equation modeling with multiple raters.

Results: RI-related etiologic factors, predominantly influenced by genes, explained 10-14% of the variance in ADHD symptoms from 8 to 9 up to 16 to 17 years. The influence of these RI-related factors on ADHD symptoms attenuated to 4% by 19 to 20 years of age. The remaining variance in ADHD symptoms was primarily explained by genetic factors independent of RI, which remained relatively stable across development, explaining 19% to 30% of the variance in ADHD symptoms from 13 to 14 up to 19 to 20 years.

Conclusion: The results show that RI is significantly associated with ADHD symptoms, particularly during childhood and adolescence, and that the association is primarily explained by a shared genetic liability. Nevertheless, the magnitude of associations across development was modest, highlighting that RI is merely one aspect contributing to the complex etiology of ADHD symptoms.

Ort, förlag, år, upplaga, sidor
Elsevier, 2016. Vol. 55, nr 10, s. 886-895
Nyckelord [en]
ADHD, immaturity, development, longitudinal twin analysis
Nationell ämneskategori
Psykiatri Psykologi Pediatrik
Identifikatorer
URN: urn:nbn:se:oru:diva-52731DOI: 10.1016/j.jaac.2016.06.014ISI: 000394072600010PubMedID: 27663944Scopus ID: 2-s2.0-84990848182OAI: oai:DiVA.org:oru-52731DiVA, id: diva2:1015358
Forskningsfinansiär
Vetenskapsrådet, 2014-3831
Anmärkning

Funding Agencies:

Swedish Research Council FORMAS project on Children and Young People's Mental Health DNR 1109/12  259-2012-40

European Union 602768

Tillgänglig från: 2016-10-04 Skapad: 2016-10-03 Senast uppdaterad: 2018-07-17Bibliografiskt granskad

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Larsson, Henrik

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Journal of the American Academy of Child and Adolescent Psychiatry
PsykiatriPsykologiPediatrik

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