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Genetic and environmental contributions to stability and change of ADHD symptoms between 8 and 13 years of age: a longitudinal twin study
Department of Child and Adolescent Psychiatry, The Karolinska Hospital, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID-id: 0000-0002-6851-3297
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
2004 (Engelska)Ingår i: Journal of the American Academy of Child and Adolescent Psychiatry, ISSN 0890-8567, E-ISSN 1527-5418, Vol. 43, nr 10, s. 1267-1275Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: To study the genetic and environmental contributions to stability and change of attention-deficit/hyperactivity disorder (ADHD) symptoms between 8 and 9 and 13 and 14 years of age.

Method: The sample included 1,480 twin pairs born in Sweden between May 1985 and December 1986. At wave 1 in 1994, when twins were 8-9 years old, 1,106 (75%) of the parents responded to a mailed questionnaire, and at wave 2 when the twins were 13-14 years old, 1,063 (73%) responded. A checklist with 14 items based on the 14 DSM-III-R symptoms for ADHD was completed. Structural equation modeling was used to analyze the data.

Results: A relatively high stability of ADHD symptoms over this 5-year period was found. This continuity was mainly due to the same genetic effects operating at both points in time. Change in symptoms between childhood and early adolescence was to a large extent due to new genetic effects in early adolescence but also due to new nonshared environmental effects that became important during adolescence.

Conclusions: The genetic stability highlights the importance of the continuing search for genes and endophenotypes of ADHD.

Ort, förlag, år, upplaga, sidor
Philadelphia, USA: Lippincott Williams & Wilkins, 2004. Vol. 43, nr 10, s. 1267-1275
Nyckelord [en]
Attention-deficit/hyperactivity disorder, longitudinal study, stability, change, twin study
Nationell ämneskategori
Medicin och hälsovetenskap Psykiatri Psykologi Pediatrik
Identifikatorer
URN: urn:nbn:se:oru:diva-54513DOI: 10.1097/01.chi.0000135622.05219.bfISI: 000224044400018PubMedID: 15381894Scopus ID: 2-s2.0-4644271465OAI: oai:DiVA.org:oru-54513DiVA, id: diva2:1064297
Tillgänglig från: 2017-01-12 Skapad: 2017-01-12 Senast uppdaterad: 2017-11-29Bibliografiskt granskad

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Larsson, Henrik

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Journal of the American Academy of Child and Adolescent Psychiatry
Medicin och hälsovetenskapPsykiatriPsykologiPediatrik

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