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Clinicopathological significance of BTF3 expression in colorectal cancer
Dept Oncolgy, Henan Province Peoples Hospital, Zhengzhou University, Zhengzhou, Peoples R China.; Fac Hlth Sci, Div Oncol, Dept Clin & Experimental Medicine, Linköping University, Linköping, Sweden.
Fac Health Science, Div Oncology, Dept Clin & Experimental Med, Linköping University, Linköping, Sweden..
Dept Stomatol, Hosp 1, Hebei Medical University, Shijiazhuang, Peoples R China.
Dept Surg, Vrinnevi Hospital, Linköping University, Norrköping, Sweden.
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2013 (Engelska)Ingår i: Tumor Biology, ISSN 1010-4283, E-ISSN 1423-0380, Vol. 34, nr 4, s. 2141-2146Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Basic transcription factor 3 (BTF3) is a general RNA polymerase II transcription factor and is also involved in apoptosis regulation. Increasing evidence shows that BTF3 is aberrantly expressed in several kinds of malignancies, but there is no study to analyze BTF3 expression in colorectal cancer (CRC) patients. Applying immunohistochemistry, we detected BTF3 in CRCs (n = 156), the corresponding distant (n = 42), adjacent normal mucosa (n = 96), lymph node metastases (n = 35), and analyzed its relationships with clinicopathological and biological variables. Our results showed that BTF3 staining significantly increased from distant or adjacent normal mucosa to primary CRCs (p < 0.0001) or metastases (p = 0.002 and p < 0.0001). BTF3 was higher in distal cancers than in proximal cancers (57 % vs. 39 %, p = 0.041). It also showed stronger staining in primary CRCs stage I and II than that in stage III and IV (64 % vs. 35 %, p = 0.0004), or metastases (64 % vs. 29 %, p = 0.004). Cancers with better differentiation had a higher expression than those with worse differentiation (56 % vs. 37 %, p = 0.031). There were positive correlations of BTF3 expression with nuclear factor kappa B (NF-kappa B), RAD50, MRE11, NBS1, and AEG-1 (p < 0.05). In conclusion, BTF3 overexpression may be an early event in CRC development and could be useful biomarker for the early stage of CRCs. BTF3 has positive correlations with NF-kappa B, RAD50, MRE11, NBS1 and AEG-1, and might influence complex signal pathways in CRC.

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Springer Netherlands, 2013. Vol. 34, nr 4, s. 2141-2146
Nyckelord [en]
Basic transcription factor 3, Biomarker, Colorectal cancer, Immunohistochemistry
Nationell ämneskategori
Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:oru:diva-54795DOI: 10.1007/s13277-013-0745-8ISI: 000321912500018PubMedID: 23532689Scopus ID: 2-s2.0-84881474571OAI: oai:DiVA.org:oru-54795DiVA, id: diva2:1066462
Forskningsfinansiär
CancerfondenVetenskapsrådet
Anmärkning

Funding agency:

Health Research Council in the southeast of Sweden 

Tillgänglig från: 2017-01-18 Skapad: 2017-01-18 Senast uppdaterad: 2018-05-27Bibliografiskt granskad

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