oru.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Does p53 codon 72 polymorphism have a prognostic value in carcinoma of the vulva and vagina?
Örebro universitet, Institutionen för medicinska vetenskaper. Department of Laboratory Medicine.
Region Örebro län. Örebro universitet, Institutionen för hälsovetenskaper. Department of Oncology.ORCID-id: 0000-0002-5063-631X
Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län. Department of Laboratory Medicine.ORCID-id: 0000-0003-2317-5738
Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län. Department of Laboratory Medicine.ORCID-id: 0000-0001-6881-237X
Vise andre og tillknytning
2017 (engelsk)Inngår i: Medical Oncology, ISSN 1357-0560, E-ISSN 1559-131X, Vol. 34, nr 3, artikkel-id 36Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Human papilloma virus (HPV) is considered to be responsible for a large part of vaginal and vulvar carcinomas, and the p53 codon 72 polymorphism has been implicated in susceptibility to cancer induced by this virus, but with contradicting results. In this study, we have investigated the prognostic value of the codon 72 polymorphism by real-time PCR (qPCR) in two cohorts of vaginal (n = 66) and vulvar (n = 123) carcinomas. In vaginal carcinoma, arginine homozygous patients were significantly associated with a higher primary cure rate (p = 0.023) but also associated with a higher recurrence rate (p = 0.073), significant at distant locations (p = 0.009). No significant differences were found in overall survival rate (p = 0.499) or cancer-specific survival rate (p = 0.222). A higher frequency of arginine homozygosity was noted in HPV-positive tumors (p = 0.190) in comparison with HPV-negative tumors. In vulvar carcinoma, the genotype homozygous for arginine was significantly associated with a larger tumor size at diagnosis in the entire cohort (p = 0.015) and a lower cancer-specific survival rate (p = 0.024) compared with heterozygous (arginine/proline) in HPV-negative tumors. Our results indicate that the relation between HPV and the p53 codon 72 polymorphism is complex and the significance and mechanisms responsible for this relationship need to be further elucidated.

sted, utgiver, år, opplag, sider
Heidelberg, Germany: Springer, 2017. Vol. 34, nr 3, artikkel-id 36
Emneord [en]
P53, Codon 72, Polymorphism, Vagina, Vulva, Carcinoma, HPV
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-55410DOI: 10.1007/s12032-017-0893-6ISI: 000394277700006PubMedID: 28144815Scopus ID: 2-s2.0-85011707902OAI: oai:DiVA.org:oru-55410DiVA, id: diva2:1080516
Merknad

Funding Agencies:

Region Örebro County through ALF

Örebro County Council Research Committee

Tilgjengelig fra: 2017-03-10 Laget: 2017-03-10 Sist oppdatert: 2019-03-22bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMedScopusPDF

Personposter BETA

Qvick, AlvidaSorbe, BengtHelenius, GiselaKarlsson, Mats G.Lillsunde Larsson, Gabriella

Søk i DiVA

Av forfatter/redaktør
Qvick, AlvidaSorbe, BengtHelenius, GiselaKarlsson, Mats G.Lillsunde Larsson, Gabriella
Av organisasjonen
I samme tidsskrift
Medical Oncology

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 330 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf