oru.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
β-Blocker after severe traumatic brain injury is associated with better long-term functional outcome: a matched case control study
Örebro universitet, Institutionen för medicinska vetenskaper. Division of Trauma and Emergency Surgery, Department of Surgery, Karolinska University Hospital, Stockholm, Sweden ; .
Department of Clinical Neuroscience, Karolinska Institutet Solna, Stockholm, Sweden.
Örebro universitet, Institutionen för medicinska vetenskaper. Division of Trauma and Emergency Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet Solna, Stockholm, Sweden.
Visa övriga samt affilieringar
2017 (Engelska)Ingår i: European Journal of Trauma and Emergency Surgery, ISSN 1863-9933, E-ISSN 1863-9941, Vol. 43, nr 6, s. 783-789Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

PURPOSE: Severe traumatic brain injury (TBI) is the predominant cause of death and disability following trauma. Several studies have observed improved survival in TBI patients exposed to β-blockers, however, the effect on functional outcome is poorly documented.

METHODS: Adult patients with severe TBI (head AIS ≥ 3) were identified from a prospectively collected TBI database over a 5-year period. Patients with neurosurgical ICU length of stay <48 h and those dying within 48 h of admission were excluded. Patients exposed to β-blockers ≤ 48 h after admission and who continued with treatment until discharge constituted β-blocked cases and were matched to non β-blocked controls using propensity score matching. The outcome of interest was Glasgow Outcome Scores (GOS), as a measure of functional outcome up to 12 months after injury. GOS ≤ 3 was considered a poor outcome. Bivariate analysis was deployed to determine differences between groups. Odds ratio and 95% CI were used to assess the effect of β-blockers on GOS.

RESULTS: 362 patients met the inclusion criteria with 21% receiving β-blockers during admission. After propensity matching, 76 matched pairs were available for analysis. There were no statistical differences in any variables included in the analysis. Mean hospital length of stay was shorter in the β-blocked cases (18.0 vs. 26.8 days, p < 0.01). The risk of poor long-term functional outcome was more than doubled in non-β-blocked controls (OR 2.44, 95% CI 1.01-6.03, p = 0.03).

CONCLUSION: Exposure to β-blockers in patients with severe TBI appears to improve functional outcome. Further prospective randomized trials are warranted.

Ort, förlag, år, upplaga, sidor
Springer Berlin/Heidelberg, 2017. Vol. 43, nr 6, s. 783-789
Nyckelord [en]
Beta-blocker; Traumatic brain injury; Functional outcome
Nationell ämneskategori
Kirurgi Neurologi
Forskningsämne
Kirurgi
Identifikatorer
URN: urn:nbn:se:oru:diva-57380DOI: 10.1007/s00068-017-0779-5ISI: 000416534600008PubMedID: 28275834Scopus ID: 2-s2.0-85014703690OAI: oai:DiVA.org:oru-57380DiVA, id: diva2:1093637
Tillgänglig från: 2017-05-08 Skapad: 2017-05-08 Senast uppdaterad: 2018-07-31Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Personposter BETA

Ahl, RebeckaSjölin, GabrielMohseni, Shahin

Sök vidare i DiVA

Av författaren/redaktören
Ahl, RebeckaSjölin, GabrielMohseni, Shahin
Av organisationen
Institutionen för medicinska vetenskaperRegion Örebro län
I samma tidskrift
European Journal of Trauma and Emergency Surgery
KirurgiNeurologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 907 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf