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Dairy intake in relation to prostate cancer survival
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston MA, United States.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston MA, United States.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston MA, United States.
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2017 (Engelska)Ingår i: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 140, nr 9, s. 2060-2069Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Dairy intake has been associated with increased risk of advanced prostate cancer. Two US cohort studies reported increased prostate cancer-specific mortality with increased high-fat milk intake. We examined whether dairy and related nutrient intake were associated with prostate cancer progression in a Swedish patient population with high dairy consumption. We prospectively followed 525 men with newly diagnosed prostate cancer (diagnosed 1989-1994). We identified and confirmed deaths through February 2011 (n = 222 prostate cancer-specific, n = 268 from other causes). Cox proportional hazards regression was used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for the associations between food or nutrient intake and prostate cancer-specific death. On average, patients consumed 5.0 servings/day of total dairy products at diagnosis. In the whole population, high-fat milk intake was not associated with prostate cancer-specific death (95% CI: 0.78, 2.10; p-trend = 0.32; multivariate-adjusted model). However, among patients diagnosed with localized prostate cancer, compared to men who consumed <1 servings/day of high-fat milk, those who drank >= 3 servings/day had an increased hazard of prostate cancer mortality (HR = 6.10; 95% CI: 2.14, 17.37; p-trend = 0.004; multivariate-adjusted model). Low-fat milk intake was associated with a borderline reduction in prostate cancer death among patients with localized prostate cancer. These associations were not observed among patients diagnosed with advanced stage prostate cancer. Our data suggest a positive association between high-fat milk intake and prostate cancer progression among patients diagnosed with localized prostate cancer. Further studies are warranted to investigate this association and elucidate the mechanisms by which high-fat milk intake may promote prostate cancer progression.

Ort, förlag, år, upplaga, sidor
Hoboken: John Wiley & Sons, 2017. Vol. 140, nr 9, s. 2060-2069
Nyckelord [en]
prostate cancer, dairy, milk, prostate cancer mortality, diet
Nationell ämneskategori
Cancer och onkologi
Forskningsämne
Onkologi
Identifikatorer
URN: urn:nbn:se:oru:diva-57668DOI: 10.1002/ijc.30642ISI: 000399313000013PubMedID: 28187509Scopus ID: 2-s2.0-85013387704OAI: oai:DiVA.org:oru-57668DiVA, id: diva2:1095910
Tillgänglig från: 2017-05-16 Skapad: 2017-05-16 Senast uppdaterad: 2018-07-31Bibliografiskt granskad

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Fall, KatjaAndersson, Swen-Olof

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Johansson, Jan-ErikAndrén, OveFall, KatjaAndersson, Swen-Olof
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