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Parkinson's disease and occupational exposures: a systematic literature review and meta-analyses
Örebro universitet, Institutionen för medicinska vetenskaper. Department of Occupational and Environmental Medicine, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.ORCID-id: 0000-0002-4192-8273
Örebro universitet, Handelshögskolan vid Örebro Universitet. Department of Statistics, Örebro University, Örebro, Sweden; Unit of Intervention and Implementation Research for Worker Health, Institute of Environmental Medicine, Karolinska Institute Solna, Stockholm, Sweden.
2017 (Engelska)Ingår i: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, E-ISSN 1795-990X, Vol. 43, nr 3, s. 197-209, artikel-id 3641Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives: We conducted a systematic literature review to identify studies fulfilling good scientific epidemiological standards for use in meta-analyses of relevant risk factors for Parkinson's disease.

Methods: Our search identified 103 original publications on associations between work and Parkinson's disease. GRADE guidelines were used to ensure high scientific quality, and reliable guidelines were applied to classify the papers. Of the 103 articles, 47 fulfilled good scientific standards while 56 were methodologically deficient and thus excluded from our meta-analyses.

Results: A total of 23 publications concerned work exposure to pesticides. The weighted relative risk estimate was 1.67 (95% confidence interval 1.42-1.97). A funnel plot and bias test indicated that some publication bias concerning smaller studies might have been present. The risk estimate was not influenced by study design (case-control, cohort, or cross-sectional study) or gender. Higher estimates were found when there was a hereditary taint or onset below age 60. Studies on exposure to metals or electromagnetic fields did not show increased risk.

Conclusions: Using an elaborated quality protocol, there is now strong evidence that exposure to any pesticide involves a ≥50% increased risk for developing Parkinson's disease.

Ort, förlag, år, upplaga, sidor
Nordic Association of Occupational Safety and Health , 2017. Vol. 43, nr 3, s. 197-209, artikel-id 3641
Nyckelord [en]
chemical; electromagnetic field; epidemiology; metal; pesticide; systematic review; welding
Nationell ämneskategori
Arbetsmedicin och miljömedicin
Forskningsämne
Arbets- och miljömedicin
Identifikatorer
URN: urn:nbn:se:oru:diva-57338DOI: 10.5271/sjweh.3641ISI: 000400705700002PubMedID: 28379585Scopus ID: 2-s2.0-85018371645OAI: oai:DiVA.org:oru-57338DiVA, id: diva2:1102673
Forskningsfinansiär
AFA Försäkring
Anmärkning

Funding Agencies:

Department of Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg 

Tillgänglig från: 2017-05-30 Skapad: 2017-05-30 Senast uppdaterad: 2018-07-31Bibliografiskt granskad

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Gunnarsson, Lars-GunnarBodin, Lennart

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Gunnarsson, Lars-GunnarBodin, Lennart
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Institutionen för medicinska vetenskaperHandelshögskolan vid Örebro Universitet
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Scandinavian Journal of Work, Environment and Health
Arbetsmedicin och miljömedicin

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