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Bioanalytical techniques in nontargeted clinical lipidomics
Steno Diabetes Center, Gentofte, Denmark; Turku Centre for Biotechnology, University of Turku, Åbo Akademi University, Turku, Finland.
Steno Diabetes Center, Gentofte, Denmark; Turku Centre for Biotechnology, University of Turku, Åbo Akademi University, Turku, Finland.ORCID iD: 0000-0002-2856-9165
2016 (English)In: Bioanalysis, ISSN 1757-6180, E-ISSN 1757-6199, Vol. 8, no 4, p. 351-364Article in journal (Refereed) Published
Abstract [en]

Lipidomic analysis aims at comprehensive characterization of molecular lipids in biological systems. Due to the central role of lipid metabolism in many devastating diseases, lipidomics is being increasingly applied in biomedical research. Over the past years, advances in analytical techniques and bioinformatics enabled increasingly comprehensive and accurate coverage of lipids both in tissues and biofluids, yet many challenges remain. This review highlights recent progress in the domain of analytical lipidomics, with main emphasis on non-targeted methodologies for large scale clinical applications, as well as discusses some of the key challenges and opportunities in this field.

Place, publisher, year, edition, pages
Future Science Ltd , 2016. Vol. 8, no 4, p. 351-364
Keywords [en]
clinical analysis; lipidomics; MS; non-targeted analysis; preanalytical factors
National Category
Cell and Molecular Biology Chemical Sciences
Identifiers
URN: urn:nbn:se:oru:diva-59374DOI: 10.4155/bio.15.244ISI: 000370072600010PubMedID: 26856187Scopus ID: 2-s2.0-84959047596OAI: oai:DiVA.org:oru-59374DiVA, id: diva2:1136143
Available from: 2017-08-25 Created: 2017-08-25 Last updated: 2018-01-13Bibliographically approved

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Hyötyläinen, TuuliaOrešič, Matej

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