oru.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Disentangling Heterogeneity of Childhood Disruptive Behavior Problems Into Dimensions and Subgroups
Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, Netherlands.
University of Notre Dame, Notre Dame IN, United States; Vrije Universiteit, Amsterdam, Netherlands.
Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, Netherlands.
Vrije Universiteit, Amsterdam, Netherlands.
Visa övriga samt affilieringar
2017 (Engelska)Ingår i: Journal of the American Academy of Child and Adolescent Psychiatry, ISSN 0890-8567, E-ISSN 1527-5418, Vol. 56, nr 8, s. 678-686Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: Irritable and oppositional behaviors are increasingly considered as distinct dimensions of oppositional defiant disorder. However, few studies have explored this multidimensionality across the broader spectrum of disruptive behavior problems (DBPs). This study examined the presence of dimensions and distinct subgroups of childhood DBPs, and the cross-sectional and longitudinal associations between these dimensions.

Method: Using factor mixture models (FMMs), the presence of dimensions and subgroups of DBPs was assessed in the Generation R Study at ages 6 (n = 6,209) and 10 (n = 4,724) years. Replications were performed in two population-based cohorts (Netherlands Twin Registry, n = 4,402, and Swedish Twin Study of Child and Adolescent Development, n = 1,089) and a clinical sample (n = 1,933). We used cross-lagged modeling in the Generation R Study to assess cross-sectional and longitudinal associations between dimensions. DBPs were assessed using mother-reported responses to the Child Behavior Checklist.

Results: Empirically obtained dimensions of DBPs were oppositional behavior (age 6 years), disobedient behavior, rule-breaking behavior (age 10 years), physical aggression, and irritability (both ages). FMMs suggested that one-class solutions had the best model fit for all dimensions in all three population-based cohorts. Similar results were obtained in the clinical sample. All three dimensions, including irritability, predicted subsequent physical aggression (range, 0.08-0.16).

Conclusion: This study showed that childhood DBPs should be regarded as a multidimensional phenotype rather than comprising distinct subgroups. Incorporating multidimensionality will improve diagnostic accuracy and refine treatment. Future studies need to address the biological validity of the DBP dimensions observed in this study; herein lies an important opportunity for neuro-imaging and genetic measures.

Ort, förlag, år, upplaga, sidor
Elsevier, 2017. Vol. 56, nr 8, s. 678-686
Nyckelord [en]
disruptive behavior disorder, classification, DSM-5, irritable mood, factor mixture model
Nationell ämneskategori
Psykologi Psykiatri Pediatrik
Identifikatorer
URN: urn:nbn:se:oru:diva-59294DOI: 10.1016/j.jaac.2017.05.019ISI: 000406895100009PubMedID: 28735697Scopus ID: 2-s2.0-85021368426OAI: oai:DiVA.org:oru-59294DiVA, id: diva2:1136787
Forskningsfinansiär
Forte, Forskningsrådet för hälsa, arbetsliv och välfärdVetenskapsrådet
Anmärkning

Funding Agencies:

European Union Seventh Framework Program (FP7): ACTION: Aggression in Children: Unravelling gene-environment interplay to inform Treatment and InterventiON strategies  602768 

Erasmus Medical Centre, Rotterdam  

Erasmus University Rotterdam  

Netherlands Organization for Health Research and Development (ZonMw)  

Netherlands Organisation for Scientific Research  NWO 480-04-004  ZonMw 9121 0020  NWO 480-15001 

Netherlands Organization for Scientific Research: NWO-grant  016.VICI.170.200

Tillgänglig från: 2017-08-29 Skapad: 2017-08-29 Senast uppdaterad: 2018-08-05Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Personposter BETA

Larsson, Henrik

Sök vidare i DiVA

Av författaren/redaktören
Larsson, Henrik
Av organisationen
Institutionen för medicinska vetenskaper
I samma tidskrift
Journal of the American Academy of Child and Adolescent Psychiatry
PsykologiPsykiatriPediatrik

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 214 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf