oru.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Female sex hormones in relation to insulin resistance after hysterectomy
Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län.
Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län.ORCID-id: 0000-0003-2636-4745
Örebro universitet, Institutionen för medicinska vetenskaper.
(engelsk)Manuskript (preprint) (Annet vitenskapelig)
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-59437OAI: oai:DiVA.org:oru-59437DiVA, id: diva2:1137814
Tilgjengelig fra: 2017-09-01 Laget: 2017-09-01 Sist oppdatert: 2017-10-18bibliografisk kontrollert
Inngår i avhandling
1. Enhanced Recovery After Hysterectomy
Åpne denne publikasjonen i ny fane eller vindu >>Enhanced Recovery After Hysterectomy
2017 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Objectives: To study recovery after hysterectomy under Enhanced Recovery After Surgery (ERAS) care, and in relation to different operation techniques.

Materials and Methods: An observational study was conducted comparing 85 patients undergoing hysterectomy with ERAS care to 120 patients immediately before establishing ERAS. In a prospective cohort study of 121 consecutive patients undergoing hysterectomy, the outcome was compared for patients with malignant versus benign indications. The main outcome measure was length of stay (LOS). A randomised controlled trial (RCT) of 20 women scheduled for hysterectomy compared robot-assisted laparoscopic with abdominal hysterectomy in terms of the development of insulin resistance, inflammatory reactions, and clinical recovery, and examined the relation to hormonal status. All studies were conducted in 2011--2015, at the Department of Obstetrics and Gynaecology, Örebro University Hospital, Sweden.

Results: Implementation of a structured ERAS protocol significantly reduced LOS compared to non-ERAS care. The effect was similar between patients with malignant and benign indications for surgery. No difference in complications was found. There was no difference in development of insulin resistance between robotic and abdominal technique, but clinical outcomes and inflammatory responses significantly favoured robot-assisted hysterectomy. Female sex hormone status was associated with the development of insulin resistance.

Conclusions: Recovery after hysterectomy can be influenced. ERAS care seems to be effective and safe. Clinical outcome can also be influenced by operational technique. Hysterectomy triggers a stress reaction in both the metabolic and the inflammatory system. It remains unclear why the reduced inflammatory reaction and favourable clinical outcome in robotic surgery were not mirrored by less insulin resistance. This could not be explained by female sex hormone status.

sted, utgiver, år, opplag, sider
Örebro: Örebro University, 2017. s. 73
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 164
Emneord
Hysterectomy, ERAS, Insulin Resistance, Female Sex hormones
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-58057 (URN)978-91-7529-203-8 (ISBN)
Disputas
2017-09-22, Örebro universitet, Campus USÖ, hörsal C2, Södra Grev Rosengatan 32, Örebro, 09:00 (svensk)
Opponent
Veileder
Tilgjengelig fra: 2017-06-15 Laget: 2017-06-15 Sist oppdatert: 2017-10-18bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Personposter BETA

Wijk, LenaLjungqvist, OlleNilsson, Kerstin

Søk i DiVA

Av forfatter/redaktør
Wijk, LenaLjungqvist, OlleNilsson, Kerstin
Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric

urn-nbn
Totalt: 265 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf