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Ten years transmission of the new variant of Chlamydia trachomatis in Sweden: prevalence of infections and associated complications
Section of Clinical Bacteriology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Örebro universitet, Institutionen för naturvetenskap och teknik. WHO Collaborating Centre for Gonorrhoea and other STIs, Örebro University Hospital, Örebro, Sweden.
Department of Clinical Microbiology, Falu Lasarett, Falun, Sweden.
Department of Clinical Microbiology, Sunderby Hospital, Luleå, Sweden.
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2018 (Engelska)Ingår i: Sexually Transmitted Infections, ISSN 1368-4973, E-ISSN 1472-3263, Vol. 94, nr 2, s. 100-104Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVES: In 2006, a new variant of Chlamydia trachomatis (nvCT) was discovered in Sweden. It has a deletion in the plasmid resulting in failed detection by the single target systems from Abbott and Roche used at that time, whereas the third system used, from Becton Dickinson (BD), detects nvCT. The proportion of nvCT was initially up to 65% in counties using Abbott/Roche systems. This study analysed the proportion of nvCT from 2007 to 2015 in four selected counties and its impact on chlamydia-associated complications.

METHODS: C. trachomatis-positive specimens collected from 2007 to 2015 were analysed by a specific PCR to identify nvCT cases. Genotyping was performed by multilocus sequence typing (MLST) and ompA sequencing. Ectopic pregnancy and pelvic inflammatory disease records were extracted from the national registers.

RESULTS: In total, 5101 C. trachomatis-positive samples were analysed. The nvCT proportion significantly decreased in the two counties using Roche systems, from 56% in 2007 to 6.5% in 2015 (p<0.001). In the two counties using BD systems, a decrease was also seen, from 19% in 2007 to 5.2% in 2015 (p<0.001). Fifteen nvCT cases from 2015 and 102 cases from 2006 to 2009 had identical MLST profiles. Counties using Roche/Abbott systems showed higher mean rates of ectopic pregnancy and pelvic inflammatory disease compared with counties using BD systems.

CONCLUSIONS: The nvCT proportion has decreased in all counties and converged to a low prevalence irrespective of previous rates. Genotyping showed that nvCT is clonal and genetically stable. Failing detection only marginally affected complication rates.

Ort, förlag, år, upplaga, sidor
BMJ Publishing Group Ltd, 2018. Vol. 94, nr 2, s. 100-104
Nyckelord [en]
chlamydia trachomatis, ectopic pregnancy, epidemiology, pelvic inflammatory disease, plasmid
Nationell ämneskategori
Mikrobiologi inom det medicinska området Infektionsmedicin
Identifikatorer
URN: urn:nbn:se:oru:diva-61756DOI: 10.1136/sextrans-2016-052992ISI: 000428207800007PubMedID: 28724744Scopus ID: 2-s2.0-85042848044OAI: oai:DiVA.org:oru-61756DiVA, id: diva2:1152561
Anmärkning

Funding Agencies:

Uppsala University Hospital  

Örebro County Council Research Committee  

Foundation for Medical Research at Örebro University Hospital, Sweden  

Tillgänglig från: 2017-10-25 Skapad: 2017-10-25 Senast uppdaterad: 2022-12-15Bibliografiskt granskad

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Hadad, RonzaFredlund, HansUnemo, Magnus

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Sexually Transmitted Infections
Mikrobiologi inom det medicinska områdetInfektionsmedicin

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