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Self-assessed remission rates after electroconvulsive therapy of depressive disorders
Örebro universitet, Institutionen för medicinska vetenskaper. (Clinical Epidemiology and Biostatistics)
Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län. Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. (Clinical Epidemiology and Biostatistics)ORCID-id: 0000-0002-3552-9153
Department of Psychiatry, Umeå University Hospital, Umeå, Sweden.
Psychiatric Neuromodulation Unit (PNU), Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden.
Vise andre og tillknytning
2017 (engelsk)Inngår i: European psychiatry, ISSN 0924-9338, E-ISSN 1778-3585, Vol. 45, s. 154-160, artikkel-id S0924-9338(17)32917-6Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Electroconvulsive therapy (ECT) effectively treats severe depression, but not all patients remit. The aim of the study was to identify clinical factors that associate with ECT-induced remission in a community setting.

METHODS: Depressed patients who underwent ECT in 2011-2014 were identified from the Swedish National Quality Register for ECT. Remission was defined as self-rated Montgomery-Åsberg Depression Rating Scale scores of 0-10 after ECT. Other registers provided data on previous antidepressant use, comorbidities, and demographics.

RESULTS: Of 1671 patients fulfilling the inclusion criteria, 42.8% achieved remission. Older age, education length over 9 years, psychotic symptoms, shorter duration of preceding antidepressant use, pulse width stimulus≥0.50ms, absence of substance use disorders, anxiety diagnosis, lamotrigine, and benzodiazepines, were associated with remission.

CONCLUSIONS: This study shows that psychotic subtype of depression and older age are clinically relevant predictors of a beneficial ECT effect. Additionally, ECT outcomes can be further improved by optimizing the treatment technique and concomitant medication.

sted, utgiver, år, opplag, sider
Elsevier Masson , 2017. Vol. 45, s. 154-160, artikkel-id S0924-9338(17)32917-6
Emneord [en]
Mania and bipolar disorder; Unipolar depression; ECT
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-61681DOI: 10.1016/j.eurpsy.2017.06.015ISI: 000414461300021PubMedID: 28865389Scopus ID: 2-s2.0-85028504905OAI: oai:DiVA.org:oru-61681DiVA, id: diva2:1156838
Forskningsfinansiär
Swedish Research Council, 523-2013-2982Swedish Foundation for Strategic Research , KF10-0039
Merknad

Funding Agency:

Region Örebro county

Tilgjengelig fra: 2017-11-14 Laget: 2017-11-14 Sist oppdatert: 2018-08-10bibliografisk kontrollert

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