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Arterial stiffness is associated to cardiorespiratory fitness and body mass index in young Swedish adults: The Lifestyle, Biomarkers, and Atherosclerosis study
Örebro universitet, Institutionen för medicinska vetenskaper.
Örebro universitet, Institutionen för hälsovetenskaper. Åstrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences, Stockholm, Sweden.
Örebro universitet, Institutionen för hälsovetenskaper.ORCID-id: 0000-0003-1067-8627
2017 (Engelska)Ingår i: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 24, nr 17, s. 1809-1818Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Early changes in the large muscular arteries are already associated with risk factors as hypertension and obesity in adolescence and young adulthood. The present study examines the association between arterial stiffness measurements, pulse wave velocity and augmentation index and lifestyle-related factors, body composition and cardiorespiratory fitness, in young, healthy, Swedish adults.

Design: This study used a population-based cross-sectional sample.

Methods: The 834 participants in the study were self-reported healthy, non-smoking, age 18-25 years. Augmentation index and pulse wave velocity were measured with applanation tonometry. Cardiorespiratory fitness was measured by ergometer bike test to estimate maximal oxygen uptake. Body mass index (kg/m(2)) was calculated and categorised according to classification by the World Health Organisation.

Results: Young Swedish adults with obesity and low cardiorespiratory fitness have significantly higher pulse wave velocity and augmentation index than non-obese young adults with medium or high cardiorespiratory fitness. The observed U-shaped association between pulse wave velocity and body mass index categories in women indicates that it might be more beneficial to be normal weight than underweight when assessing the arterial stiffness with pulse wave velocity. The highest mean pulse wave velocity was found in overweight/obese individuals with low cardiorespiratory fitness. The lowest mean pulse wave velocity was found in normal weight individuals with high cardiorespiratory fitness. Cardiorespiratory fitness had a stronger effect than body mass index on arterial stiffness in multiple regression analyses.

Conclusions: The inverse association between cardiorespiratory fitness and arterial stiffness is observed already in young adults. The study result highlights the importance of high cardiorespiratory fitness, but also that underweight individuals may be a possible risk group that needs to be further studied.

Ort, förlag, år, upplaga, sidor
Sage Publications, 2017. Vol. 24, nr 17, s. 1809-1818
Nyckelord [en]
Arterial stiffness, pulse wave analysis, cardiorespiratory fitness, body mass index, young adult, atherosclerosis
Nationell ämneskategori
Kardiologi Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
URN: urn:nbn:se:oru:diva-62511DOI: 10.1177/2047487317720796ISI: 000414856300004PubMedID: 28696134Scopus ID: 2-s2.0-85033405287OAI: oai:DiVA.org:oru-62511DiVA, id: diva2:1158985
Forskningsfinansiär
AFA FörsäkringTillgänglig från: 2017-11-21 Skapad: 2017-11-21 Senast uppdaterad: 2019-10-22Bibliografiskt granskad
Ingår i avhandling
1. Arterial stiffness and risk factors for cardiovascular disease in young adults
Öppna denna publikation i ny flik eller fönster >>Arterial stiffness and risk factors for cardiovascular disease in young adults
2019 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Atherosclerosis is a complex, chronic vessel wall disease that often leads to severe and acute cardiovascular diseases (CVD), such as myocardial infarction and stroke. CVD are the most common cause of death, both globally and in Sweden. Since most of the risk factors for atherosclerosis are preventable, it is of great importance to highlight the benefits of a healthy lifestyle to young adults who are about to create their own habits.

A general concern about physical inactivity, low cardiorespiratory fitness (CRF), and high body mass are supported by reports of an increased incidence and prevalence of obesity worldwide. In addition to this, the proportion of Swedish adults with low CRF almost doubled the last 20 years and the decline in CRF is more pronounced in the youngest age group.

The scientific work presented in this thesis was carried out to investigate the impact of different lifestyle related factors on vascular status, especially arterial stiffness, in young Swedish adults. In total 840 young adults in the age range 18-25 years were recruited to the cross-sectional Lifestyle, Biomarkers, and Atherosclerosis (LBA) study, to examine vascular status, biomarkers, and lifestyle related factors.

In the LBA study population of young adults in Sweden, 12% were classified as being at risk of future CVD. A high CVD risk was associated with low CRF and less physical activity. In the total study population 24% had unhealthy food habits, and 24% did not spend the recommended 30 minutes per day at moderate or vigorous intensities of physical activity. Low CRF, less physical activity, and overweight and obesity, were associated with stiffer arteries.

The results raises concerns about future CVD risk and highlights the health enhancing possibilities of high CRF and physical activity on vascular status in young Swedish adults.

Ort, förlag, år, upplaga, sidor
Örebro: Örebro University, 2019. s. 98
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 201
Nyckelord
Cardiovascular disease, atherosclerosis, arterial stiffness, pulse wave analysis, intima media thickness, cardiorespiratory fitness, physical activity, body composition, young adults
Nationell ämneskategori
Annan medicinsk grundvetenskap
Identifikatorer
urn:nbn:se:oru:diva-75985 (URN)978-91-7529-306-6 (ISBN)
Disputation
2019-11-15, Örebro universitet, Campus USÖ, hörsal C2, Södra Grev Rosengatan 32, Örebro, 09:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2019-08-30 Skapad: 2019-08-30 Senast uppdaterad: 2019-10-23Bibliografiskt granskad

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Fernberg, UlrikaFernström, MariaHurtig-Wennlöf, Anita

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European Journal of Preventive Cardiology
KardiologiFolkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

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