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Decreased cord-blood phospholipids in young age-at-onset type 1 diabetes
Department of Clinical Sciences, Lund University Clinical Research Centre, Skåne University Hospital, Malmö, Sweden.
VTT Technical Research Centre of Finland, Espoo, Finland.
Department of Clinical Sciences, Lund University Clinical Research Centre, Skåne University Hospital, Malmö, Sweden.
Örebro universitet, Institutionen för naturvetenskap och teknik. VTT Technical Research Centre of Finland, Espoo, Finland.ORCID-id: 0000-0002-4382-4355
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2013 (Engelska)Ingår i: Diabetes, ISSN 0012-1797, E-ISSN 1939-327X, Vol. 62, nr 11, s. 3951-3956Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Children developing type 1 diabetes may have risk markers already in their umbilical cord blood. It is hypothesized that the risk for type 1 diabetes at an early age may be increased by a pathogenic pregnancy and be reflected in altered cord-blood composition. This study used metabolomics to test if the cord-blood lipidome was affected in children diagnosed with type 1 diabetes before 8 years of age. The present case-control study of 76 index children diagnosed with type 1 diabetes before 8 years of age and 76 healthy control subjects matched for HLA risk, sex, and date of birth, as well as the mother's age and gestational age, revealed that cord-blood phosphatidylcholines and phosphatidylethanolamines were significantly decreased in children diagnosed with type 1 diabetes before 4 years of age. Reduced levels of triglycerides correlated to gestational age in index and control children and to age at diagnosis only in the index children. Finally, gestational infection during the first trimester was associated with lower cord-blood total lysophosphatidylcholines in index and control children. In conclusion, metabolomics of umbilical cord blood may identify children at increased risk for type 1 diabetes. Low phospholipid levels at birth may represent key mediators of the immune system and contribute to early induction of islet autoimmunity.

Ort, förlag, år, upplaga, sidor
American Diabetes Association , 2013. Vol. 62, nr 11, s. 3951-3956
Nationell ämneskategori
Endokrinologi och diabetes Immunologi inom det medicinska området Pediatrik
Identifikatorer
URN: urn:nbn:se:oru:diva-63686DOI: 10.2337/db13-0215ISI: 000326290700039PubMedID: 23929934Scopus ID: 2-s2.0-84890747164OAI: oai:DiVA.org:oru-63686DiVA, id: diva2:1169252
Forskningsfinansiär
VetenskapsrådetEU, FP7, Sjunde ramprogrammet, DIAPREPP 202013DiabetesförbundetKnut och Alice Wallenbergs Stiftelse
Anmärkning

Funding agencies:

Lund University Diabetes Centre

Academy of Finland

Centre of Excellence in Molecular Systems Immunology and Physiology Research 2012-2017 250114

Childhood Diabetes Foundation

Skane County Council for Research and Development

UMAS Funds 

Tillgänglig från: 2017-12-22 Skapad: 2017-12-22 Senast uppdaterad: 2019-03-04Bibliografiskt granskad

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Hyötyläinen, TuuliaOresic, Matej

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