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Glutamine supplementation does not prevent bacterial translocation after non-lethal haemorrhage in rats
Department of Surgery, Karolinska Hospital, Stockholm, Sweden.
Department of Surgery, Karolinska Hospital, Stockholm, Sweden.
Örebro universitet, Institutionen för medicinska vetenskaper. Department of Surgery, Karolinska Hospital, Stockholm, Sweden.ORCID-id: 0000-0003-2636-4745
Department of Surgery, Karolinska Hospital, Stockholm, Sweden.
Vise andre og tillknytning
1995 (engelsk)Inngår i: European Journal of Surgery, ISSN 1102-4151, E-ISSN 1741-9271, Vol. 161, nr 1, s. 3-8Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

OBJECTIVE:

To find out whether supplementation of an enteral diet with glutamine would reduce translocation of bacteria to mesenteric lymph nodes or blood after major haemorrhage in rats.

DESIGN:

Open randomised study.

SETTING:

University departments of surgery and microbiology, Sweden.

MATERIAL:

49 Sprague-Dawley rats.

INTERVENTIONS:

Rats were fed enterally for 7 days on diets supplemented with either glutamine or an isonitrogenous amount of non-essential amino acids. After feeding, 8 experimental and 8 control rats underwent sham operation; 9 and 7, respectively, underwent moderate haemorrhage (to 65 mm Hg); and 9 and 8, respectively, underwent severe haemorrhage (50 mm Hg) without reinfusion.

MAIN OUTCOME MEASURES:

Microbiological analyses of samples of blood and mesenteric lymph nodes taken 24 hours after haemorrhage.

RESULTS:

The median (interquartile) number of colony forming units/mesenteric lymph nodes after moderate haemorrhage in animals who were given glutamine supplementation was 11 (0-34) and in control animals 20 (0-178). After severe haemorrhage the corresponding figures were 199 (10-310) and 22 (0-187). No pathogens were isolated from blood cultures.

CONCLUSION:

Glutamine supplementation before haemorrhage did not reduce bacterial translocation to mesenteric lymph nodes in this rat model.

sted, utgiver, år, opplag, sider
Taylor & Francis Scandinavia , 1995. Vol. 161, nr 1, s. 3-8
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Identifikatorer
URN: urn:nbn:se:oru:diva-63853ISI: A1995QE84800001PubMedID: 7727603Scopus ID: 2-s2.0-0028813644OAI: oai:DiVA.org:oru-63853DiVA, id: diva2:1170966
Tilgjengelig fra: 2018-01-05 Laget: 2018-01-05 Sist oppdatert: 2018-02-07bibliografisk kontrollert

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