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Effects on repetitive 24-hour ambulatory blood pressure in type 2 diabetic subjects randomized to liraglutide or glimepiride treatment both in combination with metformin: A randomized open parallel-group study
Örebro universitet, Institutionen för medicinska vetenskaper.ORCID-id: 0000-0003-1025-1682
Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län. Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. (Clinical Epidemiology and Biostatistics)ORCID-id: 0000-0002-3552-9153
Central Hospital, Karlstad, Sweden.
Vise andre og tillknytning
2018 (engelsk)Inngår i: Journal of the American Society of Hypertension : JASH, ISSN 1933-1711, E-ISSN 1878-7436, Vol. 12, nr 5, s. 346-355Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

In this post hoc study, we aimed to investigate liraglutide treatment on repetitive 24-hour blood pressure (BP) in patients with type II diabetes. Sixty-two individuals with type II diabetes (45 males) were randomized to 1.8 mg liraglutide once daily or 4 mg glimepiride together with 1 g metformin twice daily. Ambulatory 24-hour systolic and diastolic blood pressure (sBP/dBP) was repetitively measured at baseline, 2 weeks, and 18 weeks. Outcomes were evaluated as treatment change from baseline, 2 weeks, and 18 weeks. Baseline clinical characteristics of liraglutide (n = 33) and glimepiride (n = 29) groups were well matched. No statistically significant difference in 24-hour sBP/dBP between three time periods and groups was observed. There was no treatment change for 24-hour sBP at week 2 or after week 18. There was a transient treatment change in 24-hour dBP in the liraglutide group at week 2 (3.2 ± 5.4 vs. -1.2 ± 4.5 mm Hg, P < .01). A treatment change in 24-hour heart rate at week 2 (4.9 ± 6.8 vs. 1.0 ± 6.0 bpm, P = .03) and at week 18 (5.9 ± 7.8 vs. 0.2 ± 6.3 bpm, P < .01) was observed in the liraglutide group. In conclusion, liraglutide treatment did not lower BP. However, a small diurnal variation in dBP without affecting BP variability or nocturnal BP dipping was observed.

sted, utgiver, år, opplag, sider
Elsevier, 2018. Vol. 12, nr 5, s. 346-355
Emneord [en]
AMBP, GLP-1 RA, sulfonurea, type 2 diabetes
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-64491DOI: 10.1016/j.jash.2018.02.003ISI: 000432644100006PubMedID: 29548934Scopus ID: 2-s2.0-85043460083OAI: oai:DiVA.org:oru-64491DiVA, id: diva2:1177122
Forskningsfinansiär
Swedish Society for Medical Research (SSMF)Swedish Society of MedicineSwedish Heart Lung FoundationNovo NordiskStockholm County CouncilThe Karolinska Institutet's Research Foundation
Merknad

Funding Agency:

Stiftelsen Serafimerlasarettet

Tilgjengelig fra: 2018-01-24 Laget: 2018-01-24 Sist oppdatert: 2018-08-20bibliografisk kontrollert

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