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Examining the Association Between Autistic Traits and Atypical Sensory Reactivity: A Twin Study
Karolinska Institutet, Stockholm, Sweden.
Child and Adolescent Psychiatry, Lund University, Lund, Sweden.
Örebro universitet, Institutionen för medicinska vetenskaper. Karolinska Institutet, Stockholm, Sweden.ORCID-id: 0000-0002-6851-3297
Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, Sweden.
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2018 (Engelska)Ingår i: Journal of the American Academy of Child and Adolescent Psychiatry, ISSN 0890-8567, E-ISSN 1527-5418, Vol. 57, nr 2, s. 96-102Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: Atypical responses to sensory stimuli are common features of autism spectrum disorders (ASD). Consequently, atypical sensory reactivity (SR) is now a diagnostic feature of ASD. Quantitative genetic research on ASD has overlooked these symptoms, however. We therefore investigated the association between autistic traits and SR using twin methods.

Method: Autistic traits and SR were assessed by 2 separate scales in 12,419 Swedish twin pairs (n = 3,586 monozygotic [MZ], n = 8,833 dizygotic [DZ]) when the twins were 9 or 12 years of age. The classic twin design estimated the degree to which etiological factors associated with autistic traits were also associated with SR, and the degree to which such shared factors explained the covariance between these phenotypes. DeFries Fulker analysis estimated the genetic correlation between screening diagnoses of ASD, defined broadly and strictly, and SR.

Results: Autistic traits and SR were both highly heritable (62%-75% and 66%-71%, respectively). There was a moderate phenotypic correlation between autistic traits and SR (r = 0.47). Genetic influences on these phenotypes correlated moderately (genetic correlation = 0.60). These overlapping genetic factors explained most of the correlation between autistic traits and SR. Genetic correlations with SR increased for broad ASD (genetic correlation = 0.72) and strict ASD (genetic correlation = 0.80).

Conclusion: The genetic overlap observed between autistic traits and SR lends quantitative genetic support to the notion that ASD and SR are strongly linked. Stich symptoms may thus comprise part of the ASD genotype, as well as phenotype. Associations persisted across all definitions of ASD, indicating a genetic link between the broader ASD phenotype and SR.

Ort, förlag, år, upplaga, sidor
Elsevier, 2018. Vol. 57, nr 2, s. 96-102
Nyckelord [en]
autism, twin study, sensory reactivity, genetics
Nationell ämneskategori
Psykiatri Pediatrik
Identifikatorer
URN: urn:nbn:se:oru:diva-65028DOI: 10.1016/j.jaac.2017.11.019ISI: 000424074800009Scopus ID: 2-s2.0-85041181247OAI: oai:DiVA.org:oru-65028DiVA, id: diva2:1183285
Forskningsfinansiär
Forte, Forskningsrådet för hälsa, arbetsliv och välfärdVetenskapsrådet
Anmärkning

Funding Agencies:

Swedish Research Council through the Swedish Initiative for Research on Microdata in the Social and Medical Sciences (SIMSAM)  340-2013-5867 

Ann Marie and Per Ahlqvist Foundation 

Tillgänglig från: 2018-02-16 Skapad: 2018-02-16 Senast uppdaterad: 2018-08-20Bibliografiskt granskad

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Larsson, Henrik

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Journal of the American Academy of Child and Adolescent Psychiatry
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