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Correlating the gut microbiome to health and disease
Örebro universitet, Institutionen för medicinska vetenskaper. (Nutrition-Gut-Brain Interactions Research Centre)ORCID-id: 0000-0001-8591-0799
Örebro universitet, Institutionen för medicinska vetenskaper. (Nutrition-Gut-Brain Interactions Research Centre)ORCID-id: 0000-0002-4204-6811
Örebro universitet, Institutionen för medicinska vetenskaper. (Nutrition-Gut-Brain Interactions Research Centre)ORCID-id: 0000-0003-3355-9452
Örebro universitet, Institutionen för medicinska vetenskaper. (Nutrition-Gut-Brain Interactions Research Centre)ORCID-id: 0000-0003-0466-1861
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2016 (Engelska)Ingår i: The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota / [ed] Niall Hyland, Catherine Stanton, Elsevier, 2016, s. 261-291Kapitel i bok, del av antologi (Refereegranskat)
Abstract [en]

The gut microbiota is a complex ecosystem consisting of a diverse population of prokaryotes that has a symbiotic relationship with its host; thus it plays a vital role for the host’s health. Our understanding of the effect of the gut microbiome in health and disease has grown substantially over the past 2 decades, mostly because of recent advances in sequencing and other high-throughput technologies. Given its high metabolic potential, close proximity to the intestinal mucosa, and interaction with the immune system, it is not surprising that the gut microbiome is an important partaker in human health. Evidence to the importance of the gut microbiome in human health and disease is the growing number of conditions now linked to changes in the resident gut microbiota, including recurrent Clostridium difficile infections, inflammatory bowel disease, irritable bowel syndrome, colorectal cancer, allergies, neurological diseases, and metabolic diseases. Research into this field of the association of the gut microbiome with health and disease continues to expand at a rapid pace as we come to accept the gut microbiome as our “second genome.” Targeting the gut microbiome to restore/modulate its composition with the use of antibiotics, probiotics, prebiotics, and even fecal microbiota transplantation is considered a promising future strategy for the development of new solutions in the treatment of various diseases associated with an imbalance in microbiota composition and functioning.

Ort, förlag, år, upplaga, sidor
Elsevier, 2016. s. 261-291
Nyckelord [en]
Gut microbiota, Immune system-related diseases, Intestinal diseases, Metabolic diseases, Nervous system-related diseases, Therapies for gut microbiota modulation
Nationell ämneskategori
Medicin och hälsovetenskap Gastroenterologi
Identifikatorer
URN: urn:nbn:se:oru:diva-65939DOI: 10.1016/B978-0-12-802304-4.00012-8Scopus ID: 2-s2.0-85011779736ISBN: 978-0-12-802304-4 (tryckt)OAI: oai:DiVA.org:oru-65939DiVA, id: diva2:1192032
Tillgänglig från: 2018-03-21 Skapad: 2018-03-21 Senast uppdaterad: 2019-04-24Bibliografiskt granskad

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Marques, Tatiana M.Holster, SavanneWall, RebeccaKönig, JuliaBrummer, Robert Jan

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Marques, Tatiana M.Holster, SavanneWall, RebeccaKönig, JuliaBrummer, Robert Jan
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Medicin och hälsovetenskapGastroenterologi

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